Evidence map›Paper›PMID 40835763›Full record

ArticleSurgical endoscopy2025

Outcomes of Zenker's peroral endoscopic myotomy (Z-POEM) for treatment of Zenker's diverticulum at our tertiary care center: a single-institution retrospective cohort study.

Konstantinos P Economopoulos, Deanna L Palenzuela Rothman, Elan Witkowski, Charudutt Paranjape, Kumar Krishnan

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Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Konstantinos P EconomopoulosDivision of Gastrointestinal and Oncologic Surgery, Department of General Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA. keconomopoulos@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-4856-0405
Deanna L Palenzuela RothmanDivision of Gastrointestinal and Oncologic Surgery, Department of General Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.
Elan WitkowskiDivision of Gastrointestinal and Oncologic Surgery, Department of General Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.
Charudutt ParanjapeDivision of Gastrointestinal and Oncologic Surgery, Department of General Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.
Kumar KrishnanDivision of Gastroenterology, Department of Internal Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTreatment of Zenker's diverticulum (ZD) has been revolutionized with the introduction of endoscopic techniques. Z-POEM has been shown to have excellent safety and efficacy. We report our experience with the Z-POEM for the treatment of ZD.

methodsThis is a single-institution retrospective study from 2020 to 2024. The primary outcome was clinical success, defined as improvement in dysphagia score to ≤ 1 without need for a reintervention the first 6 months. Secondary outcomes included technical success, rate of reintervention, and post-procedural complications.

resultsA total of 32 patients (male 62.5%, mean age 74.2 ± 10.7 years) underwent Z-POEM for treatment of Zenker's diverticulum. The mean diverticulum size was 26.7 ± 9.9 mm. The American Society of Anesthesiologists (ASA) grade was 3 in 56.3% of patients; the rest of the patients were ASA grade 2. Technical success was achieved in 100% of patients (n = 32) and clinical success was achieved in 96.9% of patients (n = 31). The mean procedure time was 48.6 ± 19.1 min. More than two thirds of the patients (68.8%) were discharged home the same day. One patient developed atrial fibrillation postprocedurally. Mean dysphagia scores improved from 1.5 ± 0.8 before the procedure to 0.09 ± 0.3 after the procedure at most recent follow-up (p < 0.001). Mean regurgitation scores improved from 2.3 ± 1.2 before the procedure to 0.13 ± 0.3 after the procedure at most recent follow-up (p < 0.001). Reintervention due to recurrence of symptoms was required in six patients (18.8%) during a mean length of follow-up of 10.8 months (range 1 to 43 months). Most of the reinterventions (80%) were required after 17 months from the initial Z-POEM.

conclusionsZ-POEM is a safe, effective, and durable treatment for Zenker's diverticulum, but reoperation is needed in 1 out of 5 patients in the short term.

Indexed as

MyotomyNatural Orifice Endoscopic SurgeryZenker DiverticulumAgedAged, 80 and overDeglutition DisordersEsophagoscopyFemaleHumansMaleMiddle AgedPostoperative ComplicationsReoperationRetrospective StudiesTertiary Care CentersTreatment OutcomeZenker's diverticulumZ-POEM

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.