Evidence map›Paper›PMID 40835759›Full record

Trial reportSurgical endoscopy2025

Fluorescence quantitative assessment of blood perfusion in the gastric conduit to reduce anastomotic leakage after esophagectomy: a randomized controlled trial.

Wenwu He, Zhiyu Li, Xuyang Deng, Kai Zheng, Chenghao Wang, Lin Peng, Yongtao Han, Xuefeng Leng, Qiuxi Zhou

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04229524 (Quantitative Assessment of the Correlation Between Blood Supply in the Gastic Conduit and the Incidence of Anastomotic Fistula With Fluorescence Angiography for Esophageal Reconstruction), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04229524 naunknown statusnot on this map

Quantitative Assessment of the Correlation Between Blood Supply in the Gastic Conduit and the Incidence of Anastomotic Fistula With Fluorescence Angiography for Esophageal Reconstruction

TypeinterventionalSponsorSichuan Cancer Hospital and Research InstituteRan2020 to 2021Enrolled246ConditionsEsophageal Squamous Cell CarcinomaArmsFluorescence angiography
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenwu He *Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.ORCID http://orcid.org/0000-0002-2477-9587
Zhiyu Li *Department of Thoracic Surgery, The People's Hospital of Leshan, Leshan, China.
Xuyang DengDepartment of Thoracic Surgery, Chinese People's Liberation Army Western, Theater General Hospital, Chengdu, China.
Kai ZhengDepartment of Thoracic Surgery, Chinese People's Liberation Army Western, Theater General Hospital, Chengdu, China.
Chenghao WangDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Lin PengDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Yongtao HanDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Xuefeng LengDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China. doc.leng@uestc.edu.cn.
Qiuxi ZhouDepartment of General Internal Medicine, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China. qiuxi_zhou@126.com.

Funding

Bethune Charitable Foundation HZB-20190528-19Sichuan Province Science and Technology Support Program 2024NSFSC0752
6 · The paper itself

Abstract

objectivesIndocyanine green (ICG) can help surgeons identify the blood perfusion distribution of the gastric conduit. The aim of our study is to utilize ICG fluorescence for quantitative assessment of blood perfusion at the anastomotic site to minimize postoperative anastomotic leakage.

methodsPatients who underwent McKeown esophagectomy with esophageal squamous cell carcinoma between August 1, 2019, and July 31, 2021, were enrolled in the study and randomly assigned to two groups. The intervention group received ICG fluorescence-guided anastomotic site selection. ICG fluorescence was used to quantitatively assess the blood perfusion fluorescence threshold at the anastomotic site in the gastric conduit, and anastomosis was performed only at sites where the fluorescence threshold exceeded the established threshold. In the control group, anastomosis was conducted at the visually evaluated site determined by the surgeon's experience.

results45 eligible patients were assigned to the intervention group, and 47 patients were allocated to the control group, respectively. Anastomotic leakage within 30 days occurred in 6.7% (3/45) of the intervention group and in 21.3% (10/47) of the control group (p = 0.021). Additionally, no differences were observed in anastomotic stenosis within 90 days, overall survival time or in the effect of neoadjuvant therapy on anastomotic leakage.

conclusionICG fluorescence can identify the areas with good perfusion in the gastric conduit and significantly reduce the occurrence of anastomotic leakage following esophagectomy.

trial registrationClinicalTrials.gov Identifier: NCT04229524.

Indexed as

Anastomotic LeakEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaEsophagectomyOptical ImagingStomachAgedAnastomosis, SurgicalFemaleFluorescenceHumansIndocyanine GreenMaleMiddle AgedIndocyanine GreenAnastomotic leakageEsophagectomyGastric conduitICG fluorescence

Identifiers

PMID40835759

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.