SynthesisTranslational psychiatry2025
Depression and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.
Synthesis in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The relationship between cardiovascular health and common mental disorders among adults aged ≤ 50 years: a systematic review of observational studies.BMC psychiatry · 2026Pooled it
- Well-being differences and changes in people with somatic and psychiatric disorders or multimorbidities: modelling COVID-19 as a global natural experiment of stress vulnerability.BMJ mental health · 2026Article
- Association between household environment and the risk of depression and anxiety among women in Bangladesh: analysis of the Bangladesh Demographic and Health Survey (2022).The Lancet regional health. Southeast Asia · 2026Article
- Global economic burden of depression in 154 countries from 2025 to 2050.Nature medicine · 2026Article
- Dose-dependent association of depression with incidence of end-stage kidney disease and all-cause mortality, CKD-JAC study: a retrospective cohort study.Clinical and experimental nephrology · 2026Article
- Reductions to health-related quality of life associated with cigarette use, e-cigarette use, and depression among US adults.medRxiv : the preprint server for health sciences · 2026Article
- The relation between oral health, depression, and anxiety among adults in Riyadh city, Saudi Arabia: a cross-sectional study.Frontiers in oral health · 2026Article
- Patterns of depressive symptoms among older adults living in long-term care homes in China: a latent class analysis.Frontiers in public health · 2026Article
- Developmental lead (pb) exposure induces anxiety and depression-like behaviorsCurrent research in toxicology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, most studies of depression are limited to a single disease endpoint.
aimsThis study aimed to conduct an umbrella review to comprehensively assess the association between depression and health outcomes.
methodUntil December 17, 2024, we conducted a systematic search of systematic reviews and meta-analyses in PubMed, Embase, and Web of Science. We reanalyzed the summary effects and 95% confidence intervals for each study using random models. We assessed the methodological quality and evidence quality of the research with A Measurement Tool to Assess Systematic Reviews 2 and Grade of Recommendations, Assessment, Development and Evaluation, classifying studies into four categories based on evidence classification criteria.
resultsWe selected a total of 72 articles from 27,150 resulting in 114 meta-analyses and 109 health outcomes. Depression exposure was associated with 23 mortality, 21 cardiovascular outcomes, 15 offspring outcomes, 9cancer outcomes, 9 neurological outcomes, 5 endocrine outcomes, 5 dental outcomes, 3 digestive outcomes, and 19 other health outcomes. Moderate-quality evidence linked depression to specific mortality in bladder cancer (Class IV), all-cause mortality in myocardial infarction (Class III), mortality within 2 years of initial assessment in coronary artery disease (Class IV), major adverse cardiovascular events after percutaneous coronary intervention (Class III), irritable bowel syndrome (insignificant), fear of falling (Class III), and frailty (Class III).
conclusionsDepression has a significant impact on health outcomes, primarily mortality and cardiovascular outcomes. However, more definitive conclusions still require randomized controlled trials or prospective studies for validation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.