ArticleScientific reports2025
A genome-wide study on gene-nutrient interactions for hyperuricemia in a large Korean cohort (KoGES).
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- ABCG2 transporter: Structural and functional associations with gout (Review).International journal of molecular medicine · 2026Review
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7 authors.
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Abstract
This study aimed to identify novel genetic variants associated with hyperuricemia risk across multiple nutrients by assessing significant gene-nutrient interactions using large-scale genome-wide association study (GWAS) data in the Korean population. A total of 48,007 individuals from the Korean Genome and Epidemiology Study dataset were included in the GWAS. Dietary intake was evaluated using a food frequency questionnaire. To identify genomic loci that interact with specific nutrients influencing hyperuricemia risk, we conducted a GWAS followed by gene-nutrient interaction analyses of genome-wide significant single-nucleotide polymorphisms (SNPs). Two SNPs with significant gene-nutrient interactions for specific nutrients were identified: rs113206751 in the Membrane-Associated Ring-CH-Type Finger 1 (MARCH1) gene and rs9393235 in the Neuroblastoma-Associated Transcript 1 (NBAT1) gene near the prolactin (PRL) gene. Among individuals consuming vitamin A above the dietary reference intake (DRI), carriers of the minor allele (A) at MARCH1-rs113206751 had a higher risk of hyperuricemia than those with the reference allele (-, no insertion) (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.38-1.93, p: 1.01 × 10
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