Evidence map›Paper›PMID 40835517›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2025

The Relationship Between Subjective Cognitive Decline and Objective Cognitive Performance in Older Adults With Treatment-Resistant Late-Life Depression: The Role of Depression Severity.

Kayla Conaty, Swathi Gujral, Erin McCarty, Ellie Rapp, Noah Schweitzer, Aristotle N Voineskos, Helen Lavretsky, Joshua S Shimony, Meryl A Butters

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pharmacotherapy of major depressive disorder in older adults: from an evidence-informed stepwise algorithm to precision medicine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kayla ConatyWestern Psychiatric Hospital (KC, ER), University of Pittsburgh Medical Center, Pittsburgh, PA.
Swathi GujralDepartment of Psychiatry (SG, MAB), University of Pittsburgh School of Medicine, Pittsburgh, PA. Electronic address: gujrals3@upmc.edu.
Erin McCartyDepartment of Neuroscience (EM), University of Pittsburgh, Pittsburgh, PA.
Ellie RappWestern Psychiatric Hospital (KC, ER), University of Pittsburgh Medical Center, Pittsburgh, PA.
Noah SchweitzerDepartment of Bioengineering (NS), University of Pittsburgh, Pittsburgh, PA.
Aristotle N VoineskosCampbell Family Mental Health Research Institute (ANV), Centre for Additions and Mental Health & Department of Psychiatry, University of Toronto, Toronto, Canada.
Helen LavretskyUniversity of California, Los Angeles (HL), Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA.
Joshua S ShimonySchool of Medicine Department of Radiology (JSS), Washington University, St. Louis, MO.
Meryl A ButtersDepartment of Psychiatry (SG, MAB), University of Pittsburgh School of Medicine, Pittsburgh, PA.

Funding

3/5 Neurocognitive and neuroimaging biomarkers: predicting progression towards dementia in patients with treatment resistant late-life depressionR01MH114969 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUTTERS, MERYL A · 2017 to 2021
$2.6M
1/5 Neurocognitive and neuroimaging biomarkers: predicting progression towards dementia in patients with treatment-resistant late-life depressionR01MH114970 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI VOINESKOS, ARISTOTLE NICHOLAS · 2017 to 2021
$2.0M
4/5 Neurocognitive and neuroimaging biomarkers: predicting progression towards dementia in late-life depressionR01MH114981 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN, NARR, KATHERINE L · 2017 to 2021
$1.8M
5/5 Neurocognitive and neuroimaging biomarkers: predicting progression toward dementia in patients with treatment resistant late-life depressionR01MH114966 · NIMH · WASHINGTON UNIVERSITY · PI SHIMONY, JOSHUA S · 2017 to 2021
$1.7M
Aerobic Exercise for Optimizing Cognitive and Brain Health In Remitted Late-Life DepressionK23MH125074 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GUJRAL, SWATHI · 2021 to 2025
$828k
NIMH NIH HHS K23 MH125074NIMH NIH HHS R01 MH114966NIMH NIH HHS R01 MH114969NIMH NIH HHS R01 MH114970NIMH NIH HHS R01 MH114981
6 · The paper itself

Abstract

objectivesExamine the role of depression severity in linking subjective and objective indicators of cognitive decline.

methods354 participants (60+) were drawn from a multicenter longitudinal neuroimaging and neurocognitive study of TRLLD (the "OPTIMUM-NEURO" study). Subjective cognitive decline (SCD) was assessed using the everyday cognition scale. Objective cognitive performance (OCP) was assessed using the Repeatable Battery for Neuropsychological Status and subtests of the Delis-Kaplan Executive Functioning System. Depression severity was assessed using the clinician-administered Montgomery-Asberg Depression Rating Scale. Statistical analysis involved demographic-adjusted linear regression models and causal mediation analysis.

resultsParticipant and study partner-reported SCD were associated with OCP in a broad range of cognitive domains. Greater depression severity was related to worse SCD and OCP but did not statistically mediate any SCD-OCP relationships.

conclusionsAmong individuals with TRLLD, higher SCD is related to greater depression severity; however, SCD and depression severity each independently relate to OCP.

Indexed as

Cognitive DysfunctionDepressive Disorder, Treatment-ResistantAgedAged, 80 and overExecutive FunctionFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsSeverity of Illness Indexcognitionlate life depressionsubjective cognitive declinetreatment-resistant late-life depression

Identifiers

PMID40835517
PMCPMC13192281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.