Evidence map›Paper›PMID 40835423›Full record

ArticleThe Journal of veterinary medical science2025

Glucose and insulin responses following streptozotocin administration for the induction of a type 1 diabetes mellitus model in Microminipig.

Maria Izumi, Kazuki Hano, Taiki Kato, Akihiro Hirata, Paing Thaw, Azusa Seki, Miyako Tanaka, Kozue Ochi, Takayoshi Suganami, Hitoshi Kitagawa and 1 more

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In one paragraph

Article in The Journal of veterinary medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maria IzumiDepartment of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
Kazuki HanoGifu University Institute for Advanced Study, Gifu University, Gifu, Japan.
Taiki KatoDepartment of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
Akihiro HirataDepartment of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
Paing ThawGifu University Institute for Advanced Study, Gifu University, Gifu, Japan.
Azusa SekiFukushima Medical Device Development Support Centre, Fukushima, Japan.
Miyako TanakaDepartment of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Kozue OchiDepartment of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Takayoshi SuganamiDepartment of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Hitoshi KitagawaGifu University Institute for Advanced Study, Gifu University, Gifu, Japan.
Masaki TakasuGifu University Institute for Advanced Study, Gifu University, Gifu, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to establish a streptozotocin-induced type 1 diabetes mellitus (DM) model in Microminipigs. Initially, a dose of 150 mg/kg streptozotocin was tested, and pigs exhibited characteristic triphasic patterns in glycemic responses: phase 1 (transient hyperglycemia), phase 2 (hypoglycemia), and phase 3 (sustained hyperglycemia). Blood glucose concentrations showed a transient increase in phase 1, and then dropped sharply in phase 2. Based on these findings, we conducted a follow-up study using a reduced streptozotocin dose of 125 mg/kg. This group exhibited glucose dynamics similar to those observed in the 150 mg/kg group, showing glucose reductions and mild lethargy. In phase 3, both groups developed sustained hyperglycemia with negligible insulin secretion, confirming the successful establishment of a type 1 DM model.

Indexed as

Blood GlucoseDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1InsulinStreptozocinAnimalsDisease Models, AnimalFemaleHyperglycemiaMaleSwineSwine, MiniatureBlood GlucoseInsulinStreptozocinMicrominipigstreptozotocintype 1 diabetes mellitus

Identifiers

PMID40835423
PMCPMC12508601

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.