Observational studyBMJ open ophthalmology2025
Comparative analysis of iris blood flow after first-eye and second-eye cataract surgeries: insights into increased pain perception in the second eye.
Observational study in BMJ open ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02182921 (Evaluation of Surgical Outcomes of Cataract Surgery), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Evaluation of Surgical Outcomes of Cataract Surgery
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10 authors.
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Abstract
objectiveTo investigate quantitative changes in iris blood flow after first-eye and second-eye cataract surgeries, and their correlation with increased pain in the second eye. METHODS AND ANALYSIS: In this prospective study, 88 eyes of 44 participants who underwent uneventful cataract surgery were followed up at enrolment, 1 day before, and 1 day, 1 week and 1 month after each eye surgery. Iris blood flow was quantified by a swept-source optical coherence tomography angiography and intraoperative pain was evaluated. Participants were divided into three groups according to time intervals between two eye surgeries: ≥1 to <2 weeks (short interval), ≥2 to ≤4 weeks (medium interval) and greater than 4 weeks (long interval).
resultsThe second eye experienced two significant increases in iris blood flow following cataract surgery: one after the first eye and the other after its own, with the latter being significantly higher than the increase observed in the operated eye after the first surgery (p<0.05). Additionally, the second eye showed higher iris blood flow density in the short interval group compared with the long and medium at specific time points (p<0.05). The bilateral pain index difference positively correlated with second eye iris blood flow density (p<0.05) and was significantly greater in the short interval group than the long interval group (p<0.05).
conclusionsIris blood flow increased in the second-operated eye post surgery compared with the first eye, which may correlate to second-eye pain. However, due to the variability in individual pain perception, a larger sample size is needed to prospectively validate our findings to improve their generalisability. TRIAL REGISTRATION NUMBER: NCT02182921.
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