Evidence map›Paper›PMID 40835226›Full record

ArticleJMIR research protocols2025

Development of a Novel Web-Based Intervention Targeting Pain-Related Outcomes in Individuals With Chronic Orofacial Pain: Protocol for a Mixed Methods Study.

Brenda C Lovette, Jafar Bakhshaie, Ronald Kulich, Jeffry R Shaefer, Hsinlin Thomas Cheng, Shuhan He, Ana-Maria Vranceanu, Jonathan Greenberg

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in JMIR research protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06754917 (Feasibility Testing of the "Face-Forward-Web" Program for Chronic Orofacial Pain), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06754917 naactive not recruitingnot on this map

Feasibility Testing of the "Face-Forward-Web" Program for Chronic Orofacial Pain

TypeinterventionalSponsorMassachusetts General HospitalRan2025 to 2026Enrolled30ConditionsOrofacial Pain, Facial PainArmsFace-Forward-Web
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brenda C LovetteCenter for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Boston, United States.ORCID 0000-0002-7698-6457
Jafar BakhshaieCenter for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Boston, United States.ORCID 0000-0002-5906-1292
Ronald KulichDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, United States.ORCID 0000-0003-3282-3952
Jeffry R ShaeferOral and Maxillofacial Surgery, Department of Surgery, Massachusetts General Hospital, Boston, United States.ORCID 0000-0003-0965-6965
Hsinlin Thomas ChengHarvard Medical School, Harvard University, Boston, MA, United States.ORCID 0000-0002-6309-7298
Shuhan HeHarvard Medical School, Harvard University, Boston, MA, United States.ORCID 0000-0002-9902-5077
Ana-Maria VranceanuCenter for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Boston, United States.ORCID 0000-0003-3994-6488
Jonathan GreenbergCenter for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Boston, United States.ORCID 0000-0002-4875-2207

Funding

Mentoring in technology enhanced mind body and lifestyle interventionsK24AT011760 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI Ana-Maria Vranceanu · 2022 to 2026
$911k
Live video mind-body treatment to prevent persistent symptoms following mTBIK23AT010653 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI GREENBERG, JONATHAN · 2020 to 2024
$790k
Development of "Face-Forward-Web": A novel web-based program targeting pain-related outcomes among patients with heterogeneous chronic orofacial painR21DE033502 · NIDCR · MASSACHUSETTS GENERAL HOSPITAL · PI GREENBERG, JONATHAN, VRANCEANU, ANA-MARIA · 2024 to 2025
$459k
NCCIH NIH HHS K23 AT010653NCCIH NIH HHS K24 AT011760NIDCR NIH HHS R21 DE033502
6 · The paper itself

Abstract

backgroundChronic orofacial pain (COP) is common, costly, and associated with substantial pain interference and emotional distress. Psychosocial treatments for COP are scarce and limited (eg, rely on talking, which is often painful for this population; require intensive resources, limiting scalability). Here, we describe the study protocol for developing Face-Forward-Web, a "talk-free" web-based mind-body intervention for patients with COP.

objectiveWe aim to (1) develop Face-Forward-Web with the aid of live-video focus groups with adults with COP and (2) optimize Face-Forward-Web and our study protocol through beta testing followed by an open feasibility trial.

methodsWe will accomplish these aims in 2 phases, incorporating user-centered design principles. For phase 1, we conducted semistructured focus groups (n=4 groups, 22 participants) with individuals with COP. We are using rapid data analysis followed by thematic analysis to gauge treatment needs, preferences, and perceptions of the proposed platform and skills. This information will inform session structure and content as well as development of a wireframe followed by a prototype. For phase 2, we will conduct beta testing (up to n=10) followed by a feasibility trial (up to n=20) with exit interviews to gather feedback. The primary outcomes are feasibility benchmarks such as recruitment (≥70% of the eligible participants will participate), acceptability (≥70% of the participants complete ≥4 or 5 sessions), credibility, expectancy (≥70% above the Credibility and Expectancy scale's midpoint), and satisfaction (≥70% above the User Experience Questionnaire's midpoint).

resultsRecruitment for phase 1 began in October 2024 and concluded in January 2025. Data analysis for phase 1 will conclude in fall 2025 and for phase 2 in 2026. Results will iteratively guide the development of the intervention.

conclusionsFace-Forward-Web will be the first talk-free web-based intervention tailored to the needs of adults with COP. Results will inform a future efficacy trial.

trial registrationClinicalTrials.gov NCT06754917; https://clinicaltrials.gov/study/NCT06754917. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/71839.

Indexed as

Chronic PainFacial PainInternet-Based InterventionAdultFeasibility StudiesFemaleFocus GroupsHumansMaleMiddle AgedPilot Projectsasynchronouschronic orofacial painmind-bodypsychosocialweb-based platform

Identifiers

PMID40835226
PMCPMC12409173

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.