ArticleThe Journal of organic chemistry2025
Palladium-Catalyzed Monoarylation of Cyclopropylamine.
Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
A novel palladium-catalyzed protocol for the monoarylation of cyclopropylamine using the sterically demanding and electron-rich adamantyl-substituted ylide-functionalized phosphine (YPhos) adYPhos is reported. This method enables the efficient coupling of a wide range of (hetero)aryl chlorides at room temperature. The reported ligand enhances the scope for the application of YPhos ligands in amination reactions on more challenging substrates. The protocol is versatile, accommodating various functional groups and extending to larger cycloalkylamines, all accessible under feasible and mild conditions.
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