Evidence map›Paper›PMID 40835209›Full record

ArticleMucosal immunology2025

Leukotriene B4 regulates T cell recognition and control of MCMV in mucosal tissues.

Lauren E Springer, Han-Zhi Rao, Oliver Abinader, Ramkrishna Mitra, Christopher M Snyder

Abstract read
In one paragraph

Article in Mucosal immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lauren E SpringerDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address: Les024@students.jefferson.edu.
Han-Zhi RaoDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address: Han-Zhi.Rao@jefferson.edu.
Oliver AbinaderDivision of Biostatistics and Bioinformatics, Department of Pharmacology, Physiology and Cancer, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address: Oliver.Abinader@jefferson.edu.
Ramkrishna MitraDivision of Biostatistics and Bioinformatics, Department of Pharmacology, Physiology and Cancer, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address: Ramkrishna.Mitra@jefferson.edu.
Christopher M SnyderDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address: Christopher.snyder@jefferson.edu.

Funding

T cell control of MCMV and tissue-localized immune suppressionR01AI146235 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI SNYDER, CHRISTOPHER M · 2020 to 2024
$2.7M
NIAID NIH HHS R01 AI146235
6 · The paper itself

Abstract

Lipid mediators play important, yet poorly understood roles in regulating immune responses. Cytomegalovirus (CMV) is a herpesvirus that persists in mucosal tissues. Prior work suggests that leukotrienes, a class of inflammatory lipid mediators, contribute to viral control. Infection with murine (M)CMV altered leukotriene and other lipid mediator production in the nasal mucosa, lungs and salivary glands of mice. Mice lacking the receptor for leukotriene B4 (BLT1

Indexed as

Cytomegalovirus InfectionsHerpesviridae InfectionsLeukotriene B4MuromegalovirusNasal MucosaReceptors, Leukotriene B4T-LymphocytesAnimalsCells, CulturedInterferon-gammaInterleukin-10LungLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutInterferon-gammaInterleukin-10Leukotriene B4Ltb4r1 protein, mouseReceptors, Leukotriene B45-lipoyxgenaseCytokinesCytomegalovirusInflammationLeukotrieneT cells

Identifiers

PMID40835209
PMCPMC12814996

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.