Evidence map›Paper›PMID 40835089›Full record

ReviewNeuropharmacology2025

Enteric glia and purinergic signaling in health and disease.

Brian D Gulbransen, Alexei Verkhratsky, Vladimir Parpura

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brian D GulbransenDepartment of Physiology, Michigan State University, East Lansing, MI, USA. Electronic address: gulbrans@msu.edu.
Alexei VerkhratskyFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; Department of Neurosciences, University of the Basque Country, Leioa, Spain; IKERBASQUE Basque Foundation for Science, Bilbao, Spain; International Joint Research Centre on Purinergic Signalling of Sichuan Province Chengdu University of Traditional Chinese Medicine, Chengdu, China; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, China; Celica, BIOMEDICAL, Technology Park 24, 1000, Ljubljana, Slovenia; Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China. Electronic address: alexej.verkhratsky@manchester.ac.uk.
Vladimir ParpuraInternational Translational Neuroscience Research Institute, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. Electronic address: vlad@zcmu.edu.cn.

Funding

Role of enteric glia in the death of neurons during gut inflammationR01DK103723 · NIDDK · MICHIGAN STATE UNIVERSITY · PI BRIAN D. GULBRANSEN · 2015 to 2026
$4.7M
Enteric glia and visceral painR01DK120862 · NIDDK · MICHIGAN STATE UNIVERSITY · PI BRIAN D. GULBRANSEN · 2019 to 2026
$3.0M
NIDDK NIH HHS R01 DK103723NIDDK NIH HHS R01 DK120862
6 · The paper itself

Abstract

We celebrate the life of our colleague Francesco Di Virgilio, who in his very last public lecture discussed purinergic signaling in neuroglia in physiology and pathophysiology. Here, we write on a subset of a unique type of peripheral neuroglia, enteric glia that accompany enteric neurons in the enteric nervous system of the gut and act to maintain homeostasis in enteric neurocircuits. Bi-directional communication between enteric neurons and glia is majorly mediated by purines. Enteric glia also play central roles in regulating the availability of extracellular purines in enteric circuits. Changes in glial purinergic signaling and control mechanisms contribute to neuroplasticity and disease susceptibility in inflammatory contexts. This review summarizes the current state of the field in understanding how enteric glia are involved in purinergic signaling in the enteric nervous system.

Indexed as

Enteric Nervous SystemNeurogliaPurinesReceptors, PurinergicSignal TransductionAnimalsHumansNeuronsPurinesReceptors, PurinergicAdenosine receptorsCa(2+) signalingEnteric gliaEnteric nervous systemP2X receptorsP2Y receptorsPurinergic signaling

Identifiers

PMID40835089
PMCPMC12885128

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.