Evidence map›Paper›PMID 40834908›Full record

ArticlePsychiatry investigation2025

Association Between Skeletal Muscle Mass Indices and Cognitive Function Among Inpatients With Stable Schizophrenia.

Dan Shuai, Binyou Wang, Duanfang Cai, Yan Guo, Xiuping Lei, Kezhi Liu, Yilin Wang

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In one paragraph

Article in Psychiatry investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Dan ShuaiDepartment of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, Zigong, China.
Binyou WangDepartment of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, Zigong, China.
Duanfang CaiDepartment of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, Zigong, China.
Yan GuoDepartment of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, Zigong, China.
Xiuping LeiDepartment of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, Zigong, China.
Kezhi LiuDepartment of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, Zigong, China.
Yilin WangDepartment of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, Zigong, China.

Funding

Key Science and Technology Plan of Zigong City 2023-YKY-12Zigong Key Science and Technology Plan 2022ZCNKY09Zigong Key Science and Technology Plan 2023-NKY-02-03Zigong Key Science and Technology Plan 2023-NKY-02-04
6 · The paper itself

Abstract

objectiveTo investigate the correlation between appendicular skeletal muscle mass (ASM)/height (ASMIht), ASM/body mass index (ASMIBMI), ASM/weight (ASMIwt), and ASM/waist circumference (ASMIwc) and cognitive function among inpatients with stable schizophrenia.

methodsThis was a cross-sectional study of 235 stable schizophrenia inpatients, including 60% males (n=141). Patient demographic information and body composition data were collected. The Montreal Cognitive Assessment-Chinese version (MoCA-C) was used to measure cognitive function. To determine the association between the muscle mass indices and cognitive function, multiple linear regressions were established.

resultsThe median age of males and females were 51 years (range 42-55) and 51 (range 39-58), respectively. Spearman's correlation analysis revealed a significant association between ASMIwc and the MoCA-C scores (r=0.323, false discovery rate [FDR]=0.004) in males, while ASMIBMI, ASMIwt, and ASMIwc (r=0.268-0.421, all FDR <0.05) were significantly correlated with MoCA-C scores in females. Furthermore, covariate-adjusted multiple linear regression analysis further confirmed that only the ASMIwc was related to MoCAC scores after controlling for relevant variables (males: β=0.565, 95% confidence interval [CI], 0.156-0.974, p=0.007; females: β=0.96, 95% CI, 0.394-1.526, p=0.001).

conclusionOur findings showed a substantial correlation between the ASMIwc and cognitive function in schizophrenia inpatients. Further validation of these data in broader study populations is now necessary.

Indexed as

Body compositionCognitive functionSchizophreniaSkeletal muscle

Identifiers

PMID40834908
PMCPMC12444197

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