ArticleNature2025
STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
–field-weighted citation impact
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Who cites it
30 citing papers in PubMed.
- Biological consequences of Z-nucleic acid sensing by ZBP1 and ADAR1.RNA biology · 2026Review
- Exploring regulated cell death in renal cell carcinoma: mechanistic insights and therapeutic perspectives.Apoptosis : an international journal on programmed cell death · 2026Review
- Mechanisms, regulation and clinical relevance of necroptosis.Nature reviews. Molecular cell biology · 2026Review
- The cGAS-STING/MITA pathway in innate antiviral immunity and beyond.Cell insight · 2026Review
- Z-Nucleic Acid-Binding Protein (ZBP)1 (DAI/DLM1) Regulation in Antiviral Cell Death Pathways.Pathogens (Basel, Switzerland) · 2026Review
- The Role of cGAS-STING-Driven PANoptosis in Neurodegenerative Diseases and Therapeutic Prospects.Cells · 2026Review
- Transcriptomic profiling of HBV transgenic mouse livers reveals ZBP1-associated necroptotic signaling.Scientific reports · 2026Article
- Selective autophagy in kidney health and disease.Nature reviews. Nephrology · 2026Review
- cGAS-STING signaling in aging and age-related diseases: therapeutic promise and precaution.Archives of pharmacal research · 2026Review
- Molecular mechanisms regulating cGAS/STING activation in health and disease.The Journal of clinical investigation · 2026Review
- The Role and Therapeutic Potential of the STING Signaling Pathway in the Pathogenesis of Diabetic Nephropathy.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Mitochondrial protein COXFA4L3 (C15ORF48) confers resistance to DNA-damaging anticancer agents by repressing mitochondrial DNA damage responses.Scientific reports · 2026Article
- Cell autonomous inflammation in VEXAS is mediated by cGAS-STING.bioRxiv : the preprint server for biology · 2026Article
- Isoprenaline alleviates diabetic kidney disease via multi-target inhibition of the cGAS-STING pathway.Bioscience reports · 2026Article
- Innate immune sensing of dietary alcohol ignites inflammation to drive alcohol-related disease.Science advances · 2026Article
- A STING for necroptosis.Cell death and differentiation · 2026Article
- STING-STAT1-ZBP1 axis orchestrates PANoptotic signaling in ischemia-reperfusion induced acute kidney injury.Cell communication and signaling : CCS · 2026Article
- From symbiosis to immunity: the evolutionary revival of mitochondrial defense programs in inflammatory diseases.Cell communication and signaling : CCS · 2026Review
- A novel necroptosis pathway: orchestrated by non-canonical STING-ZBP1 signaling.Signal transduction and targeted therapy · 2026Article
- De novo cyclic peptides allow visualisation of the monomeric and functional amyloid conformations of the kinase RIPK3.The Biochemical journal · 2026Article
Corrections and comments
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Authors and funding
18 authors.
Konstantinos KelepourasGenome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.ORCID 0000-0003-4257-9404
Julia Saggau *Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.
Debora Bonasera *Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.
Christine KieferGenome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.ORCID 0009-0005-1577-8565
Federica LocciDepartment of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany.ORCID 0000-0001-5443-0717
Hassan Rakhsh-KhorshidGenome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany.
Louisa GrauvogelDepartment of Translational Genomics, Centre of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.ORCID 0009-0001-9460-0810
Ana Beatriz VarandaCell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.
Martin PeiferDepartment of Translational Genomics, Centre of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.ORCID 0000-0002-5243-5503
Elena LoricchioDivision of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.
Antonella MontinaroCentre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK.ORCID 0000-0002-2289-9374
Marijana CroonCologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.ORCID 0000-0001-5797-5413
Aleksandra TrifunovicCologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, Cologne, Germany.
Giusi PrencipeDivision of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.
Antonella InsalacoDivision of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.
Fabrizio De BenedettiDivision of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.ORCID 0000-0001-8749-8232
Henning WalczakCell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.
Gianmaria LiccardiGenome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, Cologne, Germany. gianmaria.liccardi@uk-koeln.de.ORCID 0000-0002-2662-1281
Funding
Wellcome Trust 214342
Abstract
Conditional deletion of caspase-8 in mouse epidermal keratinocytes (Casp8
Indexed as
DNA-Binding ProteinsFas-Associated Death Domain ProteinMembrane ProteinsNecroptosisReceptors, Tumor Necrosis Factor, Type IRNA-Binding ProteinsAnimalsCaspase 8FemaleHumansKeratinocytesMaleMiceNucleotidyltransferasesProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesCasp8 protein, mouseCaspase 8DNA-Binding ProteinsFadd protein, mouseFas-Associated Death Domain ProteinMembrane ProteinsMLKL protein, mouseNucleotidyltransferasesProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesReceptors, Tumor Necrosis Factor, Type IRipk1 protein, mouseRipk3 protein, mouseRNA-Binding ProteinsSting1 protein, mouseSTING ProteinTnfrsf1a protein, mouseZbp1 protein, mouse
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.