Evidence map›Paper›PMID 40834862›Full record

ArticleCell genomics2025

The genomic history of East Asian Middle Neolithic millet- and rice-agricultural populations.

Jianxue Xiong, Yu Xu, Guoke Chen, Liping Yang, Yawei Zhou, Yiling Pan, Zhiyou Wang, Jiujiang Bai, Baoshuai Zhang, Guanghui Dong and 31 more

Abstract readHistorical Article
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Jianxue XiongInstitute of Archaeological Science, Fudan University, Shanghai 200433, China; Karamay Silk Road Digital Economy and Industrial Integration Innovation Research Center, Karamay 834000, China.
Yu XuState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.
Guoke ChenInstitute of Cultural Relics and Archaeology in Gansu Province, Lanzhou 730000, China.
Liping YangShaanxi Academy of Archaeology, Xi'an 710043, China.
Yawei ZhouSchool of Archaeology and Cultural Heritage, Zhengzhou University, Zhengzhou 450001, China.
Yiling PanShanghai Natural History Museum, Branch of the Shanghai Science & Technology Museum, Shanghai 200041, China.
Zhiyou WangShaanxi Academy of Archaeology, Xi'an 710043, China.
Jiujiang BaiChongqing Institute of Cultural Relics and Archaeology, Chongqing 400013, China; Chongqing China Three Gorges Museum (Chongqing Museum), Chongqing 400010, China.
Baoshuai ZhangUSTC Archaeometry Laboratory, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, China.
Guanghui DongKey Laboratory of Western China's Environmental Systems (Ministry of Education), College of Earth and Environmental Science, Lanzhou University, Lanzhou 730000, China.
Jingrong PeiInstitute of Cultural Relics and Archaeology, Taiyuan Cultural Relics Protection Research Institute, Taiyuan 030006, China.
Xiaomin YangFujian Provincial Key Laboratory of Philosophy and Social Sciences in Bioanthropology, Institute of Anthropology, Xiamen University, Xiamen 361005, China.
Liang ChenChina-Central Asia "The Belt and Road" Joint Laboratory on Human and Environment Research, School of Culture Heritage, Northwest University, Xi'an 710127, China.
Ningwu KangYulin Archaeological Exploration Team, Yulin 719000, China.
Yangyang WuShanxi Academy of Archaeology, Taiyuan 030001, China.
Bangyan WangState Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200433, China.
Kongyang ZhuState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.
Panxin DuState Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200433, China; Ministry of Education Key Laboratory of Contemporary Anthropology, Center for Evolutionary Biology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China.
Xiaolong LiInstitute of Cultural Heritage, Northwestern Polytechnical University, Xi'an 710000, China.
Hetong WenDepartment of History, Fudan University, Shanghai 200433, China.
Xiaolin MaState Key Laboratory of Estuarine and Coastal Research, East China Normal University, Shanghai 200241, China.
Tianyou BaiState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.
Wanfa GuZhengzhou Institute of Cultural Relics and Archaeology, Zhengzhou 450007, China.
Yu YeZhengzhou Institute of Cultural Relics and Archaeology, Zhengzhou 450007, China.
Qian WuZhengzhou Institute of Cultural Relics and Archaeology, Zhengzhou 450007, China.
Xin ChangInstitute of Archaeological Science, Fudan University, Shanghai 200433, China.
Jingze TanMinistry of Education Key Laboratory of Contemporary Anthropology, Center for Evolutionary Biology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China.
Lei GaoChongqing Institute of Cultural Relics and Archaeology, Chongqing 400013, China.
Dong GeShanghai Natural History Museum, Branch of the Shanghai Science & Technology Museum, Shanghai 200041, China.
Bicheng LiShanghai Natural History Museum, Branch of the Shanghai Science & Technology Museum, Shanghai 200041, China.
Yishi YangInstitute of Cultural Relics and Archaeology in Gansu Province, Lanzhou 730000, China.
Weiwei FengInstitute of Cultural Relics and Archaeology in Gansu Province, Lanzhou 730000, China.
Yini YangInstitute of Archaeological Science, Fudan University, Shanghai 200433, China; Department of Cultural Heritage and Museology, Fudan Univeristy, Shanghai 200433, China.
Pengfei ShengInstitute of Archaeological Science, Fudan University, Shanghai 200433, China.
Hailiang MengKaramay Silk Road Digital Economy and Industrial Integration Innovation Research Center, Karamay 834000, China.
Rui WangMinistry of Education Key Laboratory of Contemporary Anthropology, Center for Evolutionary Biology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China.
Jiajing ZhengState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.
Xin JiaSchool of Geography, Nanjing Normal University, Nanjing 210023, China; Institute of Environmental Archaeology, Nanjing Normal University, Nanjing 210023, China. Electronic address: jiaxin@njnu.edu.cn.
Li JinState Key Laboratory of Genetics and Development of Complex Phenotypes, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200433, China. Electronic address: lijin@fudan.edu.cn.
Chuan-Chao WangState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China; Ministry of Education Key Laboratory of Contemporary Anthropology, Center for Evolutionary Biology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China. Electronic address: chuanchaowang@fudan.edu.cn.
Shaoqing WenInstitute of Archaeological Science, Fudan University, Shanghai 200433, China; Ministry of Education Key Laboratory of Contemporary Anthropology, Center for Evolutionary Biology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China; MOE Laboratory for National Development and Intelligent Governance, Fudan University, Shanghai 200433, China; Center for the Belt and Road Archaeology and Ancient Civilizations, Shanghai 200433, China. Electronic address: wenshaoqing@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Yellow and Yangtze river basins in China are among the world's oldest independent agricultural centers, known for the domestication of millet and rice, respectively, yet their genetic history is poorly understood. Here, we present genome-wide data from 74 Middle Neolithic genetic samples from these regions, showing marked genetic differentiation but bidirectional gene flow, supporting a demic diffusion model of mixed farming. Yellow River populations exhibit distinct genetic substructures resulting from interactions with surrounding groups during the mid-Neolithic expansion of millet agriculture. Upper Yellow River populations are genetically linked to Tibetan Plateau populations and possess the earliest adaptive EPAS1 haplotype (∼5,800 BP) among modern humans. Meanwhile, Yangtze River rice farmers show genetic affinity with Neolithic to present-day southeast coastal China and Austronesian populations, tracing the origins of proto-Austronesians farther north to the Yangtze River. These findings offer new insights into the impact of mid-Neolithic agricultural expansion on human genetic history.

Indexed as

AgricultureEast Asian PeopleMilletsOryzaChinaGene FlowGenetics, PopulationGenomicsHaplotypesHistory, AncientHumansadaptive EPAS1 haplotypeancient DNAMiddle Neolithicproto-Austronesian originYellow and Yangtze river

Identifiers

PMID40834862
PMCPMC12791001

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