Evidence map›Paper›PMID 40834855›Full record

ArticleCell reports. Medicine2025

Genomic landscape and immunological profile of glioblastoma in East Asian patients.

Sheng Zhong, Bo Wu, Frank Dubois, Davy Deng, Johann S Bergholz, Wanming Hu, Hao Duan, Yujie Shao, Jingyi Liu, Luwei Liu and 25 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Sheng ZhongDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China; Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Bo WuLower Extremity Division, Orthopedic Trauma Department, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Frank DuboisDepartment of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Institute of Pathology, Charité, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Davy DengDepartment of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Johann S BergholzDepartment of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Wanming HuDepartment of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Hao DuanDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yujie ShaoDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Jingyi LiuDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Luwei LiuDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Sitong ChenDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Yongfei HuDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zheng ZhaoBeijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Maojin YaoState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Ke SaiDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Jian WangDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yinsheng ChenDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Chao KeDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xiangheng ZhangDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Qunying YangDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Chengcheng GuoDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Ji ZhangDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Fuhua LinDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zhenghe ChenDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Deipei LiDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zhenqiang HeDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Chang LiDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xiaobing JiangDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Jie LuDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Wenzhuo YangDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Tao JiangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address: taojiang1964@163.com.
Zhongping ChenDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. Electronic address: chenzhp@sysucc.org.cn.
Rameen BeroukhimDepartment of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: rameen@broadinstitute.org.
Jean J ZhaoDepartment of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. Electronic address: jean_zhao@dfci.harvard.edu.
Yonggao MouDepartment of Neurosurgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. Electronic address: mouyg@sysucc.org.cn.

Funding

Synthetic lethalities to cell cycle disruption in gliomaR01CA262462 · NCI · DANA-FARBER CANCER INST · PI RAMEEN BEROUKHIM, KEITH LLOYD LIGON · 2022 to 2026
$3.3M
NCI NIH HHS R01 CA262462
6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) shows profound inter- and intratumoral heterogeneity, but differences across ancestries remain understudied. We assemble the largest cohort of GBMs from East Asian patients (EAS-GBM) and perform genomic and transcriptomic analyses. Transcriptomic clustering reveals distinct EAS-GBM molecular subtypes-proliferative (PL), neurosynaptic (NS), metabolic (MB), and immunomodulatory (IM)-based on activated biological pathways. We also identify protein markers enabling subtype classification in pathology. Comparative analysis with the predominantly European-ancestry The Cancer Genome Atlas (TCGA) GBM dataset (EUR-GBM) reveals similar main drivers, though EAS-GBMs lack the epidermal growth factor receptor (EGFR)-defined classical EUR-GBM subtype. EAS PL-GBMs display CCNE1/CCND2 overexpression, with myelocytomatosis viral oncogene (MYC) signaling activation. The IM-GBM cluster exhibits an immunotherapy-responsive expression profile, corroborated by improved overall survival under immune checkpoint blockade in an external dataset. Together, our data reveal distinctive genomic features of EAS-GBMs that may inform patient stratification for targeted therapy and drug development tailored to the EAS population.

Indexed as

Brain NeoplasmsGenomicsGlioblastomaAsia, EasternEast Asian PeopleFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiddle AgedTranscriptomeEast Asian patientsgenomic landscapeglioblastoma multiformeimmunological profilemolecular subtypes

Identifiers

PMID40834855
PMCPMC12432365

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.