ArticleCell reports. Medicine2025
Rewired type I IFN signaling is linked to age-dependent differences in COVID-19.
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Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
4 citing papers in PubMed.
- Severe Fever with Thrombocytopenia Syndrome in a 1-Year-Old Boy: A Rarely Reported Case withBalkan medical journal · 2026Article
- Circulating alpha-1 antitrypsin and its c-terminal peptides differentiate bacterial from viral community-acquired pneumonia.Journal of translational medicine · 2026Article
- Cell-Intrinsic Type I Interferon Signaling as a Pleiotropic Orchestrator of CD4 T Cell Immunity.Biomolecules · 2026Review
- Dysregulated T cell responses and inflammatory cytokine profiles in patients with acute chikungunya fever: a study from Guangdong, 2025.Frontiers in cellular and infection microbiology · 2026Article
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Authors and funding
32 authors.
Lev PetrovBerlin Institute of Health (BIH) at Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Sophia BrumhardBerlin Institute of Health (BIH) at Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Sebastian WisniewskiDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Philipp GeorgBerlin Institute of Health (BIH) at Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
David HillusDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Anna HillerBerlin Institute of Health (BIH) at Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Rosario Astaburuaga-GarcíaInstitute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany; IRI Life Sciences, Humboldt-Universität zu Berlin, Berlin, Germany.
Nils BlüthgenInstitute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany; IRI Life Sciences, Humboldt-Universität zu Berlin, Berlin, Germany.
Emanuel WylerMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin Institute for Medical Systems Biology, Berlin, Germany.
Katrin VogtBerlin Institute of Health (BIH) at Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Hannah-Philine DeyBerlin Institute of Health (BIH) at Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Saskia von StillfriedInstitute of Pathology, RWTH Aachen University Hospital, Aachen, Germany.
Christina IwertBerlin Institute of Health (BIH) at Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Roman D BülowInstitute of Pathology, RWTH Aachen University Hospital, Aachen, Germany.
Bruno MärklInstitute of Pathology, Medical Faculty Augsburg, Augsburg University, Augsburg, Germany.
Lukas MaasBerlin Institute of Health (BIH) at Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Christine LangnerInstitute of Virology, Freie Universität Berlin, Berlin, Germany.
Tim MeyerDepartment of Immunology, Labor Berlin, Charité Vivantes, Berlin, Germany.
Jennifer LoskeCenter for Digital Health, Berlin Institute of Health (BIH), Charité - Universitätsmedizin Berlin, Berlin, Germany.
Roland EilsCenter for Digital Health, Berlin Institute of Health (BIH), Charité - Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Associated Partner Site Berlin, Berlin, Germany.
Irina LehmannCenter for Digital Health, Berlin Institute of Health (BIH), Charité - Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Associated Partner Site Berlin, Berlin, Germany.
Benjamin OndruschkaInstitute of Legal Medicine, University Medical Center Hamburg- Eppendorf, Hamburg, Germany.
Markus RalserDepartment of Biochemistry, Charité - Universitätsmedizin Berlin, Berlin, Germany; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Jakob TrimpertInstitute of Virology, Freie Universität Berlin, Berlin, Germany.
Peter BoorInstitute of Pathology, RWTH Aachen University Hospital, Aachen, Germany; Department of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Sammy BedouiDepartment of Microbiology and Immunology at the Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia; Institute of Experimental Immunology, University of Bonn, Berlin, Germany.
Christian MeiselDepartment of Immunology, Labor Berlin, Charité Vivantes, Berlin, Germany.
Marcus A MallBerlin Institute of Health (BIH) at Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Associated Partner Site Berlin, Berlin, Germany; German Center for Child and Adolescent Health, Partner Site Berlin, Berlin, Germany.
Victor M CormanInstitute of Virology, Charité--Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; German Centre for Infection Research (DZIF), Partner Site Charité, Berlin, Germany.
Leif Erik SanderBerlin Institute of Health (BIH) at Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Jobst RöhmelBerlin Institute of Health (BIH) at Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Associated Partner Site Berlin, Berlin, Germany.
Birgit SawitzkiBerlin Institute of Health (BIH) at Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address: birgit.sawitzki@bih-charite.de.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advanced age is the most important risk factor for severe disease or death from COVID-19, but a thorough mechanistic understanding of the molecular and cellular underpinnings is lacking. Multi-omics analysis of 164 samples from SARS-CoV-2-infected persons aged 1 to 84 years reveals a rewiring of type I interferon (IFN) signaling with a gradual shift from signal transducer and activator of transcription 1 (STAT1) to STAT3 activation in monocytes, CD4
Indexed as
AgingCOVID-19Interferon Type ISignal TransductionAdolescentAdultAgedAged, 80 and overAge FactorsB-LymphocytesCD4-Positive T-LymphocytesChildChild, PreschoolCytokinesFemaleHumansCytokinesInterferon Type ISTAT1 protein, humanSTAT1 Transcription FactorSTAT3 protein, humanSTAT3 Transcription FactorageantibodiesB cellschildrenCOVID-19immune responsemonocytesSARS-CoV-2signalingSTAT1STAT3T cellstype I IFN
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.