Evidence map›Paper›PMID 40834429›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre-mRNA.

Chenyu Li, Julian Aurelio Marschner, Yoshihiro Kusunoki, Ningxin Zhang, Xiaoxin Li, Hao Deng, Zhibo Zhao, Kanako Watanabe-Kusunoki, Zhihui Zhu, Yan Xu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre-mRNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chenyu LiDivision of Nephrology, Department of Medicine IV, Hospital of the Ludwig-Maximilians University, 80336, Munich, Germany.ORCID https://orcid.org/0000-0002-5402-584X
Julian Aurelio MarschnerDivision of Nephrology, Department of Medicine IV, Hospital of the Ludwig-Maximilians University, 80336, Munich, Germany.
Yoshihiro KusunokiDivision of Nephrology, Department of Medicine IV, Hospital of the Ludwig-Maximilians University, 80336, Munich, Germany.
Ningxin ZhangDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, 266005, China.
Xiaoxin LiDivision of Nephrology, Department of Medicine IV, Hospital of the Ludwig-Maximilians University, 80336, Munich, Germany.
Hao DengDivision of Nephrology, Department of Medicine IV, Hospital of the Ludwig-Maximilians University, 80336, Munich, Germany.
Zhibo ZhaoDepartment of Nephrology, Shanxi Provincial People's Hospital, The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, 030012, China.
Kanako Watanabe-KusunokiDivision of Nephrology, Department of Medicine IV, Hospital of the Ludwig-Maximilians University, 80336, Munich, Germany.
Zhihui ZhuDivision of Nephrology, Department of Medicine IV, Hospital of the Ludwig-Maximilians University, 80336, Munich, Germany.
Yan XuDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, 266005, China.
Stefanie SteigerDivision of Nephrology, Department of Medicine IV, Hospital of the Ludwig-Maximilians University, 80336, Munich, Germany.
Maciej LechDivision of Nephrology, Department of Medicine IV, Hospital of the Ludwig-Maximilians University, 80336, Munich, Germany.
Katalin SusztakRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, 19104, USA.
Christian SchulzDepartment of Cardiology, Klinikum der Universität München, Ludwig-Maximilians-Universität, 81377, Munich, Germany.
Hans-Joachim AndersDivision of Nephrology, Department of Medicine IV, Hospital of the Ludwig-Maximilians University, 80336, Munich, Germany.ORCID https://orcid.org/0000-0003-2434-2956

Funding

Role of the Notch Pathway in Kidney InjuryR01DK076077 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI KATALIN SUSZTAK · 2007 to 2026
$8.0M
Epigenetics of Chronic Kidney DiseaseR01DK087635 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI KATALIN SUSZTAK · 2009 to 2026
$7.0M
APOL1 associated kidney diseaseR01DK105821 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SUSZTAK, KATALIN · 2016 to 2024
$4.6M
Chinese Scholarship Council. Deutsche Forschungsgemeinschaft AN372/30-1Chinese Scholarship Council. Deutsche Forschungsgemeinschaft INST 86/1851-1 FUGGChinese Scholarship Council. Deutsche Forschungsgemeinschaft TRR332Deutsche Forschungsgemeinschaft SFB TRR332H2020 European Research Council 648274NIDDK NIH HHS R01 DK076077NIDDK NIH HHS R01 DK087635NIDDK NIH HHS R01 DK105821NIH HHS R01DK076077NIH HHS R01DK087635NIH HHS R01DK105821Prof. Martha Merrow and Dr. Francesca Sartor of the LMU generously provided access to and expertise regarding the Nikon Eclipse Ti2 microscope system GZ:INST 86/1851-1 FUGG
6 · The paper itself

Abstract

RNA-binding proteins regulate post-transcriptional gene translation, but the macrophage-specific role of Zc3h12c remains poorly characterized. Here, the role of Zc3h12c in macrophages is characterized using Tnfrsf11a

Indexed as

Alternative SplicingInflammationMacrophagesRenal Insufficiency, ChronicRNA-Binding ProteinsRNA PrecursorsAnimalsDisease Models, AnimalHumansKidneyMaleMiceMice, Inbred C57BLRNA-Binding ProteinsRNA Precursorsalternative splicinginnate immunitykidney injurymacrophagesRNA binding protein

Identifiers

PMID40834429
PMCPMC12561471

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.