ArticleEnvironmental science & technology2025
Identifying Metabolic Signatures of Bisphenol Analog Exposure: Implication for Rapid Toxicity Screening of New Alternatives.
Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exploring the Impact of E‑Waste Exposure on Childhood Blood Pressure: Metabolomics Analysis and Risk Prediction.Environment & health (Washington, D.C.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lack of toxicity assessments for bisphenol A substitutes (BPs) has resulted in a vicious circle of pollution, replacement, and repollution. Herein, we aimed to develop specific biomarkers for rapid toxic screening and evaluation. We investigated the effects of BPs exposure on 16 health indicators of liver function, kidney function, and metabolic indices. Using nontargeted and targeted metabolomics, we systematically profiled plasma metabolite alterations to elucidate potential metabolic disruptions, toxic mechanisms, and metabolic signatures. Molecular docking was used to examine the binding activity of BPs and their metabolic transformation products (MTPs) with hormone receptors, revealing potential links between biotransformation and metabolic disruption. We found that metabolic indices like cholesterol were vulnerable to BPs exposure. Exposure to bisphenol AF (BPAF), BPB, and BPAP significantly altered 554, 391, and 236 metabolites, respectively, with kynurenine and histidine identified as common metabolic signatures. Histidine/kynurenine ratio (AUC: 0.937, ACC: 0.820) exhibited superior predictive ability for distinguishing BPs exposure compared to either histidine or kynurenine alone, serving as promising biomarkers for rapid toxic evaluation of emerging BPs. Interestingly, increased formation of MTPs with weaker hormone receptor binding reduced metabolic interference, suggesting that the metabolic disruption of BPs depends on their metabolic detoxification capacity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.