Evidence map›Paper›PMID 40834055›Full record

ArticleHypertension (Dallas, Tex. : 1979)2025

Genetically Predicted Expression of Autophagy-Related Genes and Thoracic Aortic Aging: A Mendelian Randomization Study.

Karim Kohansal Vajargah, Marie-Joe Dib, Cameron Beeche, Hamed Tavolinejad, Stephen Burgess, Julio A Chirinos

Abstract readLetter
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karim Kohansal VajargahPrevention of Metabolic Disorders Research Center, Research Institute for Metabolic and Obesity Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran (K.K.V.).
Marie-Joe DibSequoia Genetics Ltd, London, United Kingdom (M.-J.D.).ORCID 0000-0001-7591-5684
Cameron BeecheDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia (C.B., H.T., J.A.C.).ORCID 0000-0002-5781-8810
Hamed TavolinejadDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia (C.B., H.T., J.A.C.).ORCID 0000-0002-0244-5914
Stephen BurgessMRC Biostatistics Unit, University of Cambridge, United Kingdom (S.B.).ORCID 0000-0001-5365-8760
Julio A ChirinosDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia (C.B., H.T., J.A.C.).ORCID 0000-0001-9035-5670

Funding

Targeting Skeletal Muscle Perfusion and Oxidative Capacity in HFpEFR01HL155599 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ZAMANI, PAYMAN · 2021 to 2025
$3.9M
Multidrug Metabolic Approach to Improve Exercise and Skeletal Muscle Oxidative Capacity in HFpEFR01HL157264 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ZAMANI, PAYMAN · 2021 to 2025
$3.5M
Blockade of calcium channels and beta adrenergic receptors for physiologic abnormalities in heart failure with preserved ejection fraction (BLOCK HFpEF)R01HL153646 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI COHEN, JORDANA B. · 2020 to 2024
$3.2M
HeartShare: Next-Generation Phenomics to Define Heart Failure Subtypes and Treatment Targets - Clinical CentersU01HL160277 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JULIO ALONSO CHIRINOS MEDINA · 2021 to 2026
$1.7M
Genetic determinants of thoracic aortic stiffness and remodelingK24AG070459 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2021 to 2025
$975k
NHLBI NIH HHS R01 HL153646NHLBI NIH HHS R01 HL155599NHLBI NIH HHS R01 HL157264NHLBI NIH HHS U01 HL160277NIA NIH HHS K24 AG070459Wellcome Trust 225790
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

agingbiologydilatationhomeostasisrisk factors

Identifiers

PMID40834055
PMCPMC7618093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.