Evidence map›Paper›PMID 40834046›Full record

ArticlePLoS neglected tropical diseases2025

Prevalence of human T-cell leukemia virus type 1 associated inflammatory myopathies (HAIM) in Salvador, Brazil.

Adriele Ribeiro França Viriato, Marcela Câmara Machado Costa, Edmar Zanoteli, Luiz Antônio R de Freitas, Thessika Hialla Almeida Araújo, Ney Boa-Sorte, Maria Fernanda Rios Grassi, Bernardo Galvão-Castro

Abstract read
In one paragraph

Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Epidemiology and Clinical Outcomes of HTLV-1: A Comprehensive Narrative Review of Endemic and Nonendemic Regions.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adriele Ribeiro França ViriatoCentro Integrativo e Multidisciplinar de HTLV, Centro de Neurociências Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil.
Marcela Câmara Machado CostaCentro Integrativo e Multidisciplinar de HTLV, Centro de Neurociências Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil.
Edmar ZanoteliFaculdade de Medicina, Universidade de São Paulo (USP), São Paulo, Brazil.
Luiz Antônio R de FreitasFaculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil.
Thessika Hialla Almeida AraújoCentro Integrativo e Multidisciplinar de HTLV, Centro de Neurociências Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil.
Ney Boa-SorteCentro Integrativo e Multidisciplinar de HTLV, Centro de Neurociências Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil.
Maria Fernanda Rios GrassiCentro Integrativo e Multidisciplinar de HTLV, Centro de Neurociências Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil.
Bernardo Galvão-CastroCentro Integrativo e Multidisciplinar de HTLV, Centro de Neurociências Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil.ORCID 0000-0002-0644-6471

Funding

National Council for Scientific and Technological Development (CNPq)National Foundation for the Development of Private Higher Education
6 · The paper itself

Abstract

backgroundHuman T-cell leukemia virus type 1 (HTLV-1) causes inflammatory diseases and is associated with various muscle abnormalities, including polymyositis. Elevated serum creatine kinase (CPK) levels are typically indicative of muscle damage.

aimsThis study aimed to determine the prevalence of HTLV-1 associated inflammatory myopathies (HAIM) in a large cohort of People living with HTLV-1 from Salvador, Brazil. Additionally, we sought to describe the clinical, laboratory, and histopathological findings of seven HTLV-1-infected patients with persistent hyperCKemia.

methodsThis study included 503 HTLV-1-infected patients from a cohort in Salvador, Brazil, who were analyzed for creatine phosphokinase (CPK) levels. Clinical, laboratory, and pathologic examinations were performed in patients whose CPK levels were above the upper limit of the normal range in the two tests performed at different time points.

resultsPolymyositis was the main cause of HAIM in the study population, with a prevalence rate of 0.6%. Two cases were diagnosed with muscular dystrophy and mitochondrial disease, and in two other patients the cause of hyperCKemia could not be determined and is currently under investigation.

conclusionPolymyositis was the main cause of HAIM in this cfohort of People living with HTLV-1.

Indexed as

HTLV-I InfectionsHuman T-lymphotropic virus 1MyositisPolymyositisAdultAgedBiopsyBrazilCreatine KinaseFemaleHumansMaleMiddle AgedMuscle, SkeletalPrevalenceRetrospective StudiesCreatine Kinase

Identifiers

PMID40834046
PMCPMC12404636

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.