SynthesisPloS one2025
Effect of exercise intensity on redox biomarkers in healthy adults: A systematic review and meta-analysis of randomized clinical trials.
Synthesis in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Exercise-induced neuropeptidergic and neurochemical neuroadaptation in stress regulation and emotional disorders.Acta neurologica Belgica · 2026Review
- Enzyme-Specific Redox Stability and Plasticity in Trained Youth Athletes: Longitudinal Analysis of SOD and GPX.International journal of molecular sciences · 2026Article
- Impact of a 24-Week Workplace Physical Activity Program on Oxidative Stress Markers, Metabolic Health, and Physical Fitness: A Pilot Study in a Real-World Academic Setting.Journal of functional morphology and kinesiology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis meta-analysis aimed to establish the effect of vigorous and non-vigorous exercise interventions on biomarkers of redox status in healthy adults. MATERIALS AND
methodsBased on the PRISMA guidelines, we searched the following databases: Scopus, Web of Science, PubMed, Springer, Science Direct, Cochrane Library, Dialnet, Redalyc, and Lilacs for randomized controlled clinical trials investigating the effect of non-vigorous and vigorous chronic exercise in healthy adults, with the evaluation of antioxidants. The quality of evidence and risk of biases were assessed using the PEDro scale and version 2 of the Cochrane tool for risk of bias assessment in randomized trials (RoB2).
resultsSeven randomized clinical trials evaluating nine training protocols were included (n=267). Individual evaluations demonstrated an increase in antioxidant capacity (I2=0%, Z=4.56, p<0.00001) and superoxide dismutase (I2=52%, Z=1.94, p=0.05), an antioxidant enzyme, and decrease in pro-oxidant (I2=0%, Z=5.91, p<0.0001); there was no significant difference in glutathione peroxidase (I2=81%, Z=0.50, p=0.62). The effect of vigorous interventions showed an increase in antioxidants (Z=2.44, I2=67%, p=0.01) and a decrease in oxidants (Z=5.44, I2=0%, p<0.00001), while in non-vigorous exercise, no significant differences were observed in redox status.
conclusionsThe vigorous physical exercise presented better results on antioxidant and oxidative capacity compared to non-vigorous intensity training protocols in healthy people. Finding the optimal balance between exercise intensity and oxidative stress is crucial for maximizing the production of antioxidant enzymes, which can enhance physiological function and increase resistance to OS.
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Registered trials
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