ArticlePloS one2025
Unveiling the anti-aging of radix saposhnikoviae: A metabolomic study in Drosophila.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is characterized by a progressive decline in physiological functions and an increased susceptibility to age-related diseases, yet effective interventions remain limited. Recent advancements in understanding the molecular mechanisms of aging have highlighted pathways such as insulin-like signaling, mTOR, and sirtuins. Meanwhile, traditional medicinal herbs are increasingly recognized for their potential to modulate these pathways. However, comprehensive analyses investigating how these herbs influence multiple aging-related metabolic pathways simultaneously remain scarce. This study examines the anti-aging and antioxidant effects of Radix Saposhnikoviae (Fangfeng) through metabolomic analysis using Drosophila melanogaster as a model organism. Our findings indicate that different Fangfeng preparations significantly extended the lifespan of Drosophila to varying extents. Utilizing nuclear magnetic resonance (NMR) metabolomics, we identified key metabolic pathways modulated by Fangfeng, including those related to energy metabolism, oxidative stress response, lipid metabolism, protein homeostasis, and inflammatory processes-each closely associated with aging. The results revealed significant regulation of these pathways, particularly those involved in oxidative stress and energy homeostasis, which are central to the aging process. These findings underscore the potential of Radix Saposhnikoviae as a promising medicinal herb for modulating key biochemical pathways associated with aging and oxidative stress. This study provides a scientific basis for the integration of traditional herbal medicine into contemporary anti-aging strategies, contributing to the expanding field of aging research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.