ArticlePloS one2025
Factors associated with optic disc parameters and circumpapillary retinal nerve fiber layer thickness in 8-year-old children: The Yamanashi Adjunct Study of the Japan Environment and Children's Study.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to investigate the relationships between the circumpapillary retinal nerve fiber layer thickness (cpRNFL) and optic disc parameters and associated factors in 8-year-old Japanese children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children's Study (JECS). SUBJECTS AND
methodsThe participants in this study were 559 8-year-old Japanese children (277 boys and 282 girls) who participated in the Yamanashi Adjunct Study of JECS at the University of Yamanashi from June 2021 to March 2022. The visual acuity, spherical equivalent (SE), and axial length (AL) of the participants were measured. The cpRNFL thickness was measured with a spectral domain optical coherence tomograph (NIDEK RS-3000 Advance, Gamagori, Japan).
resultsThe data of 349 participants (182 boys and 167 girls) were ultimately analyzed. Multivariable analysis showed that AL was significantly positively correlated with the cpRNFL thickness in the 8 o'clock sector (β = 0.26; 95% confidence interval (CI) 2.74-6.87) and significantly negatively correlated with the cpRNFL thickness in the 6 o'clock sector (β = -0.21; 95%CI -9.94--2.98). The cpRNFL thickness in the 10 o'clock and 11 o'clock sectors was greater for girls than for boys (β = 0.21; 95%CI 2.54-8.34; and β = 0.15; 95%CI 1.85-11.99, respectively), whereas in the 12 o'clock sector, it was greater for boys (β = -0.26; 95%CI -20.41--8.32). The disc area was significantly positively correlated with the cpRNFL thickness in the 7 o'clock, 10 o'clock and 11 o'clock sectors (β = 0.13, 95%CI 0.93-8.67; β = 0.13, 95%CI 10.36-23.88; and β = 0.27, 95%CI 10.36-23.88, respectively).
conclusionThe thickness of the cpRNFL in 8-year-old Japanese children was associated with AL, sex, and disc area, but these associations differed by RNFL sector.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.