Evidence map›Paper›PMID 40833940›Full record

ArticleThe oncologist2025

Quality or quantity of life? Treatment priorities in older adults with cancer in the community.

Gabriel Aleixo, Julianne Ani, Ramy Sedhom

Abstract read
In one paragraph

Article in The oncologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Personalizing cancer care for older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gabriel AleixoDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.ORCID 0000-0002-9329-6044
Julianne AniPenn Medicine Princeton Health, Penn Medicine, Plainsboro, NJ 08540, United States.
Ramy SedhomDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Older adults with cancer often face decisions about prioritizing quality of life, survival, or both. In this prospective study of 181 patients aged ≥65 at a community cancer center, patients completed a geriatric assessment (GA) that included a validated trade-off question: "Maintaining my quality of life is more important to me than living longer." Preferences were categorized as prioritizing quality of life, quantity of life, or both. Older age (OR 1.06; P = .04) and female sex (Odds Ratio 2.82; P = .01) were associated with prioritizing quality of life. Functional, cognitive, or psychosocial impairments were not. Prioritizing quality of life was not associated with worse overall survival (Hazard Ratio 1.06; P = .89). Receipt of standard treatment improved survival (HR 0.38; P = .04), while Performance status 3-4 predicted worse outcomes. These findings challenge assumptions that prioritizing quality of life compromises survival and support the integration of GA and values-based discussions into cancer care.

Indexed as

NeoplasmsQuality of LifeAgedAged, 80 and overFemaleGeriatric AssessmentHumansMaleProspective Studiesgeriatric oncologyincurable cancer community oncologypatient preferencequality of life

Identifiers

PMID40833940
PMCPMC12449121

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.