Evidence map›Paper›PMID 40833931›Full record

ArticleRheumatology (Oxford, England)2026

The Michael Mason prize: development and feasibility testing of a complex intervention to improve adherence to fracture prevention medicine.

Laurna Bullock, Natasha Tyler, Jane Fleming, Emma M Clark, Simon Thomas, Christopher Gidlow, Cynthia P Iglesias-Urrutia, Robert Horne, Ida Bentley, Ashley Hawarden and 10 more

Abstract read
In one paragraph

Article in Rheumatology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Laurna BullockCentre for Musculoskeletal Health Research, School of Medicine, Keele University, Staffordshire, UK.ORCID 0000-0002-4193-1835
Natasha TylerFaculty of Biology, Medicine and Health, NIHR School for Primary Care Research, University of Manchester.ORCID 0000-0001-8257-1090
Jane FlemingCambridge Public Health, University of Cambridge, Cambridge, UK.ORCID 0000-0002-8127-2061
Emma M ClarkFaculty of Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0001-8332-9052
Simon ThomasPrescribing Decision Support Ltd, Cheshire, UK.
Christopher GidlowKeele Impact Accelerator Unit, School of Medicine, Keele University, Staffordshire, UK.
Cynthia P Iglesias-UrrutiaDanish Centre for Healthcare Improvement (CHI), Aalborg University, Aalborg, Denmark.
Robert HorneCentre for Behavioural Medicine, UCL School of Pharmacy, University College London, London, UK.
Ida BentleyKeele Research User Group, School of Medicine, Keele University, Staffordshire, UK.
Ashley HawardenCentre for Musculoskeletal Health Research, School of Medicine, Keele University, Staffordshire, UK.ORCID 0000-0002-5462-579X
Nicola PeelSchool of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Celia L GregsonMusculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0001-6414-0529
Stuart H RalstonCentre for Genetic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID 0000-0002-2804-7586
Joanne ProtheroeCentre for Musculoskeletal Health Research, School of Medicine, Keele University, Staffordshire, UK.ORCID 0000-0002-9608-1487
Janet LefroyCentre for Musculoskeletal Health Research, School of Medicine, Keele University, Staffordshire, UK.
Sarah RyanHaywood Academic Rheumatology Centre, Midlands Partnership University NHS Foundation Trust, Stoke-on-Trent, Staffordshire, UK.ORCID 0000-0002-2202-6266
Terence W O'NeillCentre for Epidemiology Versus Arthritis, University of Manchester, Manchester, UK.ORCID 0000-0002-8896-4677
Christian MallenCentre for Musculoskeletal Health Research, School of Medicine, Keele University, Staffordshire, UK.ORCID 0000-0002-2677-1028
Clare JinksCentre for Musculoskeletal Health Research, School of Medicine, Keele University, Staffordshire, UK.ORCID 0000-0002-3407-2446
Zoe PaskinsCentre for Musculoskeletal Health Research, School of Medicine, Keele University, Staffordshire, UK.ORCID 0000-0002-7783-2986

Funding

National Institute for Health and Care Research CS-2018-18-ST2-010National Institute for Health and Care Research (NIHR) Academy, the Royal Osteoporosis Society and Haywood FoundationNIHRNIHR Applied Research Collaboration West Midlands NIHR200165
6 · The paper itself

Abstract

objectivesOnly 12% of people recommended fracture prevention medicines remain on treatment 1 year post fracture. The 'improving uptake of Fracture Prevention treatments' (iFraP) intervention aims to improve shared decision-making (SDM) about, and uptake of, osteoporosis medicines in Fracture Liaison Services (FLS). This paper details development and feasibility.

methodsIntervention development was underpinned by (i) theories of SDM, medicines adherence and behaviour change; (ii) integrated findings from seven development studies; and (iii) extensive patient and clinician contribution, identifying key 'needs' to address and the intervention's content, functionality and scope. Feasibility testing was conducted at one English FLS. Intervention consultations were observed and audio recorded. Interviews completed with FLS clinicians and patients explored perceived acceptability and feasibility.

resultsIntervention development identified patient and clinician unmet needs for personalized and evidence-based information about osteoporosis, its consequences, and its treatment within and after FLS consultations, to facilitate clinical and SDM about medicines. The prototype intervention (osteoporosis decision support tool, clinician skills training and information resources) was designed to meet identified needs and overcome barriers to use. Clinicians delivered the prototype iFraP intervention in 10 consultations with consenting patients. Findings demonstrated that the intervention was acceptable and feasible to deliver, with potential to improve patient outcomes. The intervention was refined to support implementation.

conclusionThe multi-facilitated approach to intervention development and testing ensured that the iFraP intervention appears acceptable and feasible for use in UK FLS to support SDM about osteoporosis medicines. The iFraP trial will evaluate implementation, and cost and clinical effectiveness.

Indexed as

Bone Density Conservation AgentsDecision Making, SharedMedication AdherenceOsteoporosisOsteoporotic FracturesAgedFeasibility StudiesFemaleHumansMaleMiddle AgedBone Density Conservation Agentsadherencebehaviour changefracture liaison serviceintervention developmentosteoporosisperson-centred careshared decision-making

Identifiers

PMID40833931
PMCPMC12862368

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.