Evidence map›Paper›PMID 40833867›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Temporal effects of sympathetic denervation on aortic remodeling and rupture in experimental abdominal aortic aneurysm.

Calvin L Chao, Caitlyn Dang, Aurea R Del Carmen, Nidhi K Reddy, Taylor K Brown, Mark K Eskandari, Bin Jiang

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Calvin L ChaoDivision of Vascular Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.ORCID 0000-0002-5738-3351
Caitlyn DangDivision of Vascular Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.ORCID 0009-0001-0555-0509
Aurea R Del CarmenDivision of Vascular Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.ORCID 0009-0009-1809-1004
Nidhi K ReddyDivision of Vascular Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.
Taylor K BrownDepartment of Biomedical Engineering, Northwestern University McCormick School of Engineering, Chicago, Illinois, United States.
Mark K EskandariDivision of Vascular Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.
Bin JiangDivision of Vascular Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.ORCID 0000-0003-2390-4312

Funding

Vascular Surgery Scientist Training ProgramT32HL094293 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ESKANDARI, MARK K · 2009 to 2023
$4.0M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 5T32HL094293-14NHLBI NIH HHS T32 HL094293Vascular & Endovascular Surgery Society 2023 Resident Research Award
6 · The paper itself

Abstract

Abdominal aortic aneurysm (AAA) is a life-threatening condition with no effective pharmacologic therapies, and increasing evidence suggests that the sympathetic nervous system (SNS) contributes to disease progression. However, the temporal effects of SNS modulation on AAA stability remain unclear. To investigate the impact of SNS modulation on aneurysm outcomes, we induced AAAs in male

Indexed as

Aorta, AbdominalAortic Aneurysm, AbdominalAortic RuptureSympathectomySympathetic Nervous SystemVascular RemodelingAngiotensin IIAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, Knockout, ApoEOxidopamineTime FactorsAngiotensin IIOxidopamineabdominal aortic aneurysmangiotensin IIdenervationsympathetic nervous system

Identifiers

PMID40833867
PMCPMC12430726

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.