ArticleCell reports2025
An endogenous cluster of target-directed microRNA degradation sites induces decay of distinct microRNA families.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Target-site dynamics explain a large share of apparent microRNA differential expression.RNA (New York, N.Y.) · 2026Article
- Copper-sensitive OsSPL9 TF regulates expression of indica rice domestication-associated miRNAs and phenotypes.Communications biology · 2026Article
- CLASHub is an integrated database and analytical platform for microRNA-target interactions.Nature communications · 2026Article
- A lncRNA drives developmentally timed decay of all members of an essential microRNA family.Genes & development · 2026Article
- Linking miRNAs to decay.Genes & development · 2026Article
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- Article
- mRNA 3' UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth.Genes & development · 2026Article
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- The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation.bioRxiv : the preprint server for biology · 2026Article
- mRNA 3' UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth.bioRxiv : the preprint server for biology · 2025Article
- Spatiotemporal Control of microRNA-Target Interactions.Wiley interdisciplinary reviews. RNAReview
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8 authors.
Funding
Abstract
While much is known about microRNA (miRNA) biogenesis and targeting, relatively less is understood about miRNA decay. Target-directed miRNA degradation (TDMD) is a mechanism in metazoans where certain RNAs can "trigger" miRNA decay. All known TDMD triggers base pair with the miRNA seed, and extensively base pair on the miRNA 3' end, a pattern that is believed to be a requirement for miRNA turnover. Using Ago1-CLASH, we find that the Drosophila transcript Kah contains at least two triggers, a "trigger cluster," against miR-9b and the miR-279 family. One trigger contains minimal/non-canonical 3' end base-pairing but is still sufficient to induce TDMD of the miR-279 family. We find that these clustered triggers lack cooperativity, that minimal 3' pairing is required for miR-279 family turnover, and probed the in-cell structure of the Kah trigger cluster. Overall, we expand the list of endogenous TDMD triggers, which revealed unexpectedly complex regulation in miRNA turnover.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.