Evidence map›Paper›PMID 40833724›Full record

ReviewMolecular biotechnology2026

Advancements in CRISPR-Cas Systems for Genome Editing towards Eradication of Human Microbial Pathogens.

Gargi Bhattacharjee, Nisarg Gohil, Khushal Khambhati, Karan Murjani, Dinh Toi Chu, Nhat Le Bui, Hue Vu Thi, Indra Mani, Abhisheka Bansal, Sasanala Shamili and 4 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gargi BhattacharjeeDepartment of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, 382715, India.
Nisarg GohilDepartment of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, 382715, India.
Khushal KhambhatiDepartment of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, 382715, India.
Karan MurjaniDepartment of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, 382715, India.
Dinh Toi ChuThe Interdisciplinary Research Group on Biomedicine and Health (IRGBH), International School, Vietnam National University, Hanoi, Vietnam.
Nhat Le BuiThe Interdisciplinary Research Group on Biomedicine and Health (IRGBH), International School, Vietnam National University, Hanoi, Vietnam.
Hue Vu ThiThe Interdisciplinary Research Group on Biomedicine and Health (IRGBH), International School, Vietnam National University, Hanoi, Vietnam.
Indra ManiDepartment of Microbiology, Gargi College, University of Delhi, Siri Fort Road, New Delhi, 110049, India.
Abhisheka BansalSchool of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Sasanala ShamiliThe Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, 84105, Beer Sheva, Israel.
Lakkakula SatishMarine Algal Research Station, CSIR-Central Salt Marine and Chemicals Research Institute, Mandapam Camp, Mandapam, Tamil Nadu, 623519, India.
Suresh RamakrishnaGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul, South Korea.
Khalid J AlzahraniDepartment of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, 21944, Taif, Saudi Arabia.
Vijai SinghDepartment of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, 382715, India. vijaisingh15@gmail.com.ORCID http://orcid.org/0000-0002-6394-4370

Funding

Department of Biotechnology BT/PR38411/GET/119/311/2020National Science foundation of Korea 2021M3A9H3015390Taif University TU-DSPP-2024-05
6 · The paper itself

Abstract

CRISPR-Cas systems have been explored for targeted genome editing of several organisms. It is rapid, cost-effective, specific, and versatile technology. It requires expression of multidomain single Cas9 protein and single guide RNA (sgRNA) that targets desired nucleic acids in the presence of a protospacer adjacent motif (PAM). This generates a double-stranded break that is repaired by either non-homologous end joining or a homology-directed repair pathway. Currently, several Cas protein variants have been discovered and being used for several biotechnological applications. This review highlights the recent progress of CRISPR-Cas systems for genome editing of mainly human pathogenic microorganisms for their controlling infections.

Indexed as

CRISPR-Cas SystemsGene EditingBacteriaHumansRNA, Guide, CRISPR-Cas SystemsRNA, Guide, CRISPR-Cas SystemsCRISPR–Cas systemsDiagnosticGenome editingMicroorganismsTherapy

Identifiers

PMID40833724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.