Evidence map›Paper›PMID 40833658›Full record

ArticleJournal of autism and developmental disorders2025

Associations of Adaptive Behavior and Wandering with Serious Injuries in Young Children with Autism: Study to Explore Early Development.

C DiGuiseppi, B Holst, M Bolt, S J Schmiege, K Bartholomay, B Barger, T Crume, S Levy, C Nadler, L A Schieve and 2 more

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

C DiGuiseppiDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Carolyn.DiGuiseppi@cuanschutz.edu.ORCID http://orcid.org/0000-0002-6440-7817
B HolstDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
M BoltDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
S J SchmiegeDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
K BartholomayDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
B BargerDepartment of Population Health Sciences, Mark Chaffin Center for Health and Development (Disability Branch), School of Public Health, Georgia State University, Atlanta, GA, USA.
T CrumeDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
S LevyCenter for Autism Research, Perelman School of Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
C NadlerDivision of Developmental and Behavioral Health, Children's Mercy Kansas City, Kansas City, MO, USA.
L A SchieveNational Center on Birth Defects & Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
L H TianNational Center on Birth Defects & Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
L D WigginsNational Center on Birth Defects & Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Funding

CDC HHS U10DD000180CDC HHS U10DD000181CDC HHS U10DD000182CDC HHS U10DD000183CDC HHS U10DD000184CDC HHS U10DD000498Intramural CDC HHS CC999999
6 · The paper itself

Abstract

purposeIncreased injury risk in children with autism may result from co-occurring developmental characteristics and challenges. We examined associations of adaptive behavior delay and wandering with injuries among children with autism.

methodsCross-sectional analyses were performed using data from 648 children aged 30-68 months with autism determined by standardized instruments. Associations of adaptive behavior delay and wandering with any parent-reported serious injury (i.e., resulting in emergency department visit or hospitalization) since birth were examined, adjusting for age and attention-deficit/hyperactivity problems. Effect modification by significant early learning delay (SELD) was assessed.

resultsPrevalence of serious injury was 27%. Delayed adaptive behavior occurred in 81% and wandering sometimes or often in 59%. Associations of both adaptive behavior and wandering with serious injury differed by SELD status. Among children with SELD, adjusted prevalence of serious injury was increased in those with normal adaptive behavior (47%) versus delayed adaptive behavior (24%) (adjusted prevalence ratio [aPR] = 2.01; 95% confidence interval (CI): 1.17, 3.45, p = 0.011) and in those who wandered often or sometimes (30%) versus those who did not (18%) (aPR = 1.50; 95%CI: 1.01, 2.25, p = 0.047). Among children without SELD, neither normal adaptive behavior (aPR = 0.82; 95%CI: 0.54, 1.32; p = 0.336) nor wandering (aPR = 0.88; 95%CI: 0.59, 1.30; p = 0.516) was significantly associated with serious injury.

conclusionAmong children with autism, there appears to be a complex interplay among wandering and adaptive behavior, SELD and injury occurrence. Children with autism and SELD who have normal adaptive behavior or who wander may be important targets for injury prevention interventions.

Indexed as

Adaptive behaviorAutism spectrum disorderInjuriesWandering

Identifiers

PMID40833658
PMCPMC12990144

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.