Evidence map›Paper›PMID 40833605›Full record

ArticleMikrochimica acta2025

Lysozyme detection in body biofluids by dual-decorated graphene oxide-gold nanoparticles-based biomimetic plasmonic sensor.

Seçkin Kılıç, Fatma Yılmaz, Semra Akgönüllü, Ilgım Göktürk, Adil Denizli

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Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Seçkin KılıçGraduate School of Science and Engineering, Department of Chemistry, Hacettepe University, 06800, Ankara, Turkey.
Fatma YılmazDepartment of Chemistry Technologies, Bolu Abant Izzet Baysal University, 14030, Bolu, Turkey.
Semra AkgönüllüBiochemistry Division, Department of Chemistry, Hacettepe University, Ankara, Turkey.
Ilgım GöktürkBiochemistry Division, Department of Chemistry, Hacettepe University, Ankara, Turkey.
Adil DenizliGraduate School of Science and Engineering, Department of Chemistry, Hacettepe University, 06800, Ankara, Turkey. denizli@hacettepe.edu.tr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate measurement of lysozyme in human biofluids is essential for early disease diagnosis and treatment monitoring. This work presents a plasmonic sensing platform utilizing AuNPs-GO/MIP, which integrates gold nanoparticles (AuNPs) and graphene oxide (GO) through molecular imprinting for the detection of lysozyme in urine, serum, and saliva. The enhancement in sensor sensitivity resulting from the addition of AuNPs and GO was verified by comparing it with a sensor lacking these components. We fabricated a AuNPs-GO/MIP surface plasmon resonance (SPR) chip using N-methacryloyl-L-cysteine and N-methacryloyl-L-tryptophan as functional monomers; the platform enables sensitive, low-cost, label-free lysozyme detection in buffer and synthetic biofluids, with no additional coupling chemistry. The imprinting efficiency was evaluated with a non-imprinted AuNPs-GO/NIP SPR sensor, yielding a remarkable imprinting factor (IF: 4.98). The sensor showed a linear detection response (R

Indexed as

Biomimetic MaterialsGoldGraphiteMetal NanoparticlesMuramidaseSurface Plasmon ResonanceHumansLimit of DetectionMolecular ImprintingSalivaGoldgraphene oxideGraphiteMuramidaseBiomimetic sensingLysozyme detectionMolecularly imprinted polymerSurface plasmon resonance

Identifiers

PMID40833605

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.