ArticleAging clinical and experimental research2025
Multimorbidity patterns and mortality in older adults: a two-cohort pooled analysis.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Patterns of multimorbidity, their outcomes and analytical methods for their determination: a systematic review.BMC public health · 2026Pooled it
- Multimorbidity patterns and mental health in late life: a systematic review of longitudinal studies.European geriatric medicine · 2026Pooled it
- Patterns of multimorbidity and in-hospital kidney function decline in older adults: a latent class analysis of three acute-care cohorts.Internal and emergency medicine · 2026Article
- Integrated Risk Stratification Using Comorbidity Burden, Frailty, and Systemic Inflammation to Predict 30-Day Mortality in Older Emergency Department Patients: A Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Multimorbidity Patterns and Mortality Risk in a National Sample of US Adults Identified Using Latent Class Analysis.Diseases (Basel, Switzerland) · 2026Article
- Comorbidity Burden Is Associated with Claims-Based Muscle Wasting and Atrophy Suggestive of Possible Sarcopenia in Korean Adults: A Propensity Score-Matched Analysis Using the National Health Insurance Service Database.Healthcare (Basel, Switzerland) · 2026Article
- Clinical Trials in Older Adults with Cardiovascular Multimorbidity: A Perspective on Pragmatic Trial Design.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
backgroundDifferent multimorbidity patterns can affect health trajectories and influence survival.
aimsWe investigated their association with mortality in two population-based cohorts of older adults.
methodsTwo Italian cohorts of randomly selected individuals (60–79 years old) from general population: CUORE (baseline 2008–2012) and Moli-sani (baseline 2005–2010). Latent Class Analysis used to identify homogeneous groups of multimorbid individuals (≥ 2 diseases) with similar underlying disease patterns. Cox regression models used to assess the association of multimorbidity patterns and all-cause mortality (end of follow-up 12/31/2019). Results pooled in a random-effects meta-analysis.
resultsTotal samples of 3,695 individuals in CUORE (48% male, mean age 68.8 years [SD 5.6]) and 7,801 in Moli-sani (51% male, mean age 68.2 years [SD 5.4]). In both cohorts, six multimorbidity patterns were identified and named after their overexpressed diseases: hypercholesterolemia; metabolic, depression and cancer; cardiometabolic and respiratory; gastrointestinal, genitourinary and depression; respiratory; unspecific (i.e., no diseases overexpressed). Overall mortality rates were 1.66 per 100 person/years in CUORE and 1.85 per 100 person/years in Moli-sani. Compared to the multimorbidity-free group (< 2 diseases), individuals displaying a cardiometabolic and respiratory pattern showed the highest mortality (pooled HR 2.62, 95% CI 2.15–3.10), followed by unspecific (pooled HR 1.45, 95% CI 1.21–1.68), respiratory (pooled HR 1.33, 95% CI 1.01–1.64) and gastrointestinal, genitourinary and depression (pooled HR 1.33, 95% CI 1.06–1.60). DISCUSSION: Multimorbidity patterns in older adults are differentially associated to shorter survival.
conclusionsTheir identification may help optimize clinical management by improving risk stratification, allowing for more targeted prevention and intervention strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.