ArticleAnnals of surgical oncology2025
Outcome of Conversion Surgery After Induction Therapy for Esophageal Cancer with Synchronous Para-Aortic Lymph Node Metastasis: A Multi-institutional Retrospective Study.
Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Characteristic pathological findings of achalasia behind unresectable esophageal cancer with pathological complete response after chemotherapy: a case report and literature review.BMC gastroenterology · 2026Review
- Reassessing the role of combined organ resection in cT4b esophageal cancer: feasibility, outcomes, and future directions.Journal of thoracic disease · 2026Article
- Successful Combination Immunotherapy for Postoperative Recurrence of Esophageal Cancer Following Prior Immune Checkpoint Inhibitor Treatment: A Case Report.Surgical case reports · 2026Article
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20 authors.
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Abstract
backgroundSystemic chemotherapy is the standard treatment for esophageal cancer with synchronous distant metastasis including para-aortic lymph node (PALN) metastasis. The significance of conversion surgery for esophageal cancer with synchronous PALN metastasis remains controversial.
objectiveThe current study aimed to investigate the clinical outcome of conversion surgery for esophageal cancer with synchronous PALN metastasis after induction therapy.
methodsThis multi-institutional retrospective study included 48 patients with esophageal cancer who exhibited synchronous PALN metastasis and who received induction chemotherapy or chemoradiotherapy followed by conversion surgery between 2005 and 2022. The short- and long-term treatment outcomes were examined.
resultsAmong the 48 patients, 45 and 3 received chemotherapy and chemoradiotherapy, respectively, as the initial treatment. Moreover, all patients underwent subtotal esophagectomy. The incidence rate of postoperative complications was 48% and the in-hospital mortality rate was 2%. The 3- and 5-year overall survival rates of all patients were 36.1% and 25.2%, respectively. The overall survival rates of patients with pN2-3 and final PALN status (fM1) were significantly lower than that of patients with pN0-1 (p = 0.0025) and fM0 (p = 0.0043). The multivariate analysis showed that pathological nodal status (hazard ratio 2.44, p = 0.0488) and fM status (hazard ratio 2.53, p = 0.0246) were independent prognostic factors.
conclusionsConversion surgery for esophageal cancer with synchronous PALN metastasis is feasible and promising. In addition, conversion surgery for patients with controlled nodal status including PALN metastasis is important for long-term prognosis.
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