ReviewCurrent opinion in HIV and AIDS2025
Harnessing innate immunity: natural killer cells and innate immune responses in reservoir clearance.
Review in Current opinion in HIV and AIDS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- HIV controllers, lessons learnt from the lymphoid tissues.Current opinion in HIV and AIDS · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewAs the HIV pandemic persists in the absence of an effective vaccine, this review summarizes promising recent strategies harnessing natural killer cells as part of the innate immune system for HIV cure. RECENT
findingsCurrent HIV cure approaches aim to enhance natural killer (NK) cell function by reversing inhibition, cytokine-mediated activation and targeting reservoir tissues. Additionally, HIV-specific NK cell therapies include broadly neutralizing antibody-mediated antibody-dependent cellular cytotoxicity, bispecific antibodies and adoptive NK cell transfers. To date, none of the strategies by themselves showed sufficient efficacy, highlighting the importance of integrated approaches combining multiple NK cell-based strategies as well as considering the interplay between the innate and adaptive immune response to HIV-1. SUMMARY: Encouraging findings from in vitro studies, animal models and clinical trials studying innovative NK cell-based therapies demonstrate their potential for cure strategies. Different strategies may need to be combined to create synergy to overcome the major challenge represented by the latent viral reservoir.
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Registered trials
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