Evidence map›Paper›PMID 40833410›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child.

Louise Turner, Teresa Nunez de Villavicencio Diaz, Sai Sundar Rajan Raghavan, Ikhlaq Hussain Kana, Eric Lyimo, Chelsea Reitzel, Christian W Wang, Ewen Berube, Rasmus W Jensen, Johannes R Loeffler and 9 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Louise TurnerCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen 2200, Denmark.ORCID 0000-0003-4494-2289
Teresa Nunez de Villavicencio DiazRapid Novor, Kitchener, ON N2G 4X8, Canada.ORCID 0000-0002-3303-8836
Sai Sundar Rajan RaghavanCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen 2200, Denmark.ORCID 0000-0002-2575-2685
Ikhlaq Hussain KanaCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen 2200, Denmark.ORCID 0000-0003-1342-4737
Eric LyimoNational Institute for Medical Research, Tanga Research Centre, Tanga W4M6+Q54, Tanzania.ORCID 0000-0002-1904-7410
Chelsea ReitzelRapid Novor, Kitchener, ON N2G 4X8, Canada.ORCID 0009-0006-3971-2752
Christian W WangCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen 2200, Denmark.ORCID 0000-0003-3140-6989
Ewen BerubeCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen 2200, Denmark.
Rasmus W JensenCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen 2200, Denmark.
Johannes R LoefflerDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
Monica Lisa Fernández-QuinteroDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
Thor G TheanderCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen 2200, Denmark.ORCID 0000-0002-3509-7514
John P A LusinguNational Institute for Medical Research, Tanga Research Centre, Tanga W4M6+Q54, Tanzania.
Thierry Le BihanRapid Novor, Kitchener, ON N2G 4X8, Canada.ORCID 0000-0003-0498-8063
Xiaobing HanRapid Novor, Kitchener, ON N2G 4X8, Canada.
Daniel T R MinjaNational Institute for Medical Research, Tanga Research Centre, Tanga W4M6+Q54, Tanzania.ORCID 0000-0001-6159-4664
Andrew B WardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.ORCID 0000-0001-7153-3769
Bin MaRapid Novor, Kitchener, ON N2G 4X8, Canada.ORCID 0000-0001-6254-4087
Thomas LavstsenCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen 2200, Denmark.ORCID 0000-0002-3044-4249

Funding

Independent Research Fund of Denmark 4285-00205BKirsten & Freddy Johansens Fond 2023Lundbeck Foundation (Lundbeckfonden) R344-2020-934The Novo Nordisk Fonden NNF23OC0086433
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibodies, ProtozoanImmunoglobulin GMalaria, FalciparumPlasmodium falciparumProtozoan ProteinsAntibodies, MonoclonalChildEndothelial Protein C ReceptorErythrocytesHumansMass SpectrometryAntibodies, MonoclonalAntibodies, ProtozoanEndothelial Protein C Receptorerythrocyte membrane protein 1, Plasmodium falciparumImmunoglobulin GProtozoan Proteinsbroadly inhibitory antibodiescryo-EMmalariamonoclonal antibodyPfEMP1

Identifiers

PMID40833410
PMCPMC12403141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.