ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2026
In-kind Nutritional Supplementation for Persons With Drug-susceptible Tuberculosis and Their Household Contacts Would be Cost-effective for Reducing Tuberculosis Incidence and Mortality in Jharkhand, India: A Modeling Study.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Cost-effectiveness of in-kind nutritional support for impoverished persons with tuberculosis to reduce mortality and disengagement from care in India: a modelling study.BMJ global health · 2026Article
- From DOTS to DOST: a new framework for TB elimination in India.The Lancet regional health. Southeast Asia · 2026Review
- Drug-resistant tuberculosis in war and complex emergencies: jeopardising progress towards TB elimination and antimicrobial resistance control - a scoping review and perspective.BMJ global health · 2026Article
- Combination interventions to control the tuberculosis epidemic in the Karamoja subregion of Uganda: A modelling analysis.PLOS global public health · 2026Article
- Tuberculosis- learning about experience with nutritional supplementation (TB LENS): Perspectives on a nutritional supplementation for persons with TB and their household contacts.Global public health · 2025Article
- Article
Corrections and comments
- Update of
Authors and funding
9 authors.
Funding
Abstract
backgroundUndernutrition is the leading cause of tuberculosis (TB) globally, but nutritional interventions are often considered cost-prohibitive. The RATIONS study demonstrated that nutritional supplementation to household contacts of persons with TB can reduce TB incidence, yet economic evaluations of such strategies remain limited.
methodsUsing a Markov model, we assessed the cost-effectiveness of a RATIONS-style intervention (monthly food basket providing 750 kcal, 23 g of protein, and a multi-micronutrient tablet daily) for household contacts of persons with TB, as compared to no nutritional support. We calculated health outcomes (TB episodes, TB deaths, and disability-adjusted life years [DALYs]) over the lifetime of intervention recipients and assessed costs from healthcare and societal perspectives. We tested the robustness of results to parameter changes via deterministic and probabilistic sensitivity analysis.
findingsOver 2 years, household contacts receiving the RATIONS intervention experienced 38% (95% uncertainty interval [UI]: 23-52) fewer TB episodes and 58% (95% UI: 44-70) fewer TB deaths. Over the lifetime of a cohort of 100 000 household contacts, the intervention was projected to avert 11 524 DALYs (95% UI: 7446-17 393) and was cost-effective from both the healthcare (incremental cost-effectiveness ratio [ICER]: $289 per DALY averted [95% UI: 156-537]) and societal perspectives ($229 per DALY averted [95% UI: 102-468]). Cost-effectiveness was most sensitive to the cost of the nutritional supplement.
conclusionsPrompt nutritional support for household contacts of persons with TB disease would be cost-effective in reducing TB incidence and mortality in India.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.