Evidence map›Paper›PMID 40832960›Full record

ArticleFuture oncology (London, England)2025

Clinical outcome and influencing factors of differentiated thyroid cancer with biochemical incomplete response.

Congcong Wang, Guohua Qin, Shuhui Wang, Yutian Li, Yaqi Lu, Xia Shen, Wei Sun, Jiao Li, Na Han, Chenghui Lu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Congcong WangDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.ORCID 0000-0003-1793-3301
Guohua QinDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Shuhui WangDepartment of Radiology, Qingdao Women and Children's Hospital, Qingdao, Shandong, China.
Yutian LiDepartment of Radiology, Qingdao Women and Children's Hospital, Qingdao, Shandong, China.
Yaqi LuDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Xia ShenDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Wei SunDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Jiao LiDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Na HanDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Chenghui LuDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Guoqiang WangDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yingying ZhangDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
ZengHua WangDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Zengmei SiDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Fengqi LiDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Xufu WangDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yansong LinDepartment of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences & PUMC, Beijing, China.
Xinfeng LiuDepartment of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of our study was to investigate the clinical outcomes and predictive factors in patients with biochemical incomplete response (BIR) after initial radioiodine therapy (RAI). MATERIALS &

methodsThis retrospective study enrolled 198 patients with BIR from two institutions and stratified them into a training cohort (Qingdao cohort, n = 144) and an external validation cohort (Beijing cohort, n = 54). The patients were classified as having incomplete response (IR) or non-IR disease at the final follow-up. Univariate and multivariate analyses identified IR predictors in the training cohort. A nomogram was developed using the training cohort and was validated in the validation cohort using calibration curves, decision curve analysis (DCA), and receiver operating characteristic analysis.

resultsAge, recurrence risk, pre-stimulated thyroglobulin (ps-Tg), and BRAF

conclusionsThis validated nomogram provides a clinically useful tool for quantifying IR risk in BIR patients, supporting personalized management decisions after initial RAI.

Indexed as

Iodine RadioisotopesNeoplasm Recurrence, LocalThyroid NeoplasmsAdultAgedBiomarkers, TumorFemaleHumansMaleMiddle AgedMutationNomogramsPrognosisProto-Oncogene Proteins B-rafRetrospective StudiesROC CurveBiomarkers, TumorBRAF protein, humanIodine RadioisotopesProto-Oncogene Proteins B-rafThyroglobulinbiochemical incomplete responseDifferentiated thyroid cancerprognosisradioiodine therapytherapeutic response

Identifiers

PMID40832960
PMCPMC12439549

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.