Evidence map›Paper›PMID 40832916›Full record

ReviewFEBS letters2025

The nicotinamide hypothesis revisited-plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione.

Torkel Berglund, Anna B Ohlsson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in FEBS letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Torkel BerglundDepartment of Industrial Biotechnology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.
Anna B OhlssonDepartment of Industrial Biotechnology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-5368-4296

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A previously presented hypothesis, here updated, proposed nicotinamide produced by the activity of poly(ADP-ribose) polymerase (PARP) as a stress signaling compound in plants. PARP activation by DNA strand breaks caused by oxidative stress leads to the metabolization of NAD to ADP-ribose units and nicotinamide. Also, NAD-degrading histone deacetylases (sirtuins) produce nicotinamide. We suggest that nicotinamide, either alone or acting through its metabolite nicotinic acid, will generate epigenetic changes in the plant. We propose that this is an early step in a general stress response, making the DNA more accessible to the transcription machinery and specific stress signaling substances to activate the defense genes needed for the present stress situation. The role of glutathione in this context is discussed.

Indexed as

Epigenesis, GeneticGlutathioneNiacinNiacinamidePlantsPoly(ADP-ribose) PolymerasesSignal TransductionOxidative StressGlutathioneNiacinNiacinamidePoly(ADP-ribose) PolymerasesdefenseDNA hypomethylationepigeneticsglutathionehistone acetylationnicotinamidenicotinic acidpoly(ADP‐ribose) polymerasereactive oxygen speciesstress signaling

Identifiers

PMID40832916
PMCPMC12643062

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.