ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Lipid profiling reveals unsaturated lipid reduction in women with Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Ovarian somatic tissue rejuvenates circulating apolipoproteins and promotes cognitive health in postreproductive female mice.GeroScience · 2026Article
- Article
- Shared Risk Genes and Casual Relationships across Sex Hormone Related Traits and Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2026Article
- Association between lipid profiles and early clinical outcomes in acute ischemic stroke: a single-center cohort study in the Chinese population.BMC neurology · 2025Article
- Lipid profiling reveals unsaturated lipid reduction in women with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Hippocampal mediation in the lipid-Alzheimer's disease pathway: A high-dimensional mediation analysis stratified byAlzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
8 authors.
Funding
Abstract
introductionAlzheimer's disease (AD) is a devastating neurological disease that disproportionately affects women. This study aimed to investigate sex-specific single lipids associated with AD.
methodsPlasma samples from 841 participants, comprising 306 individuals with AD, 165 with mild cognitive impairment (MCI), and 370 cognitively healthy controls were curated from the AddNeuroMed cohort. Lipidomics identified 268 single lipids for each sample. We investigated sex-specific associations from lipid modules and single lipids to AD and probed for causality with mediation analyses.
resultsThree modules associated with AD in the female subset and one in the male subset (P < 0.05). In the female participants with AD, lipid families containing highly unsaturated fatty acids were reduced and those containing saturated lipids were increased (q value < 0.05). The effects of unsaturated phospholipids on AD were not mediated via cholesterol, low-density lipoprotein, or apolipoprotein B. DISCUSSION: Women with AD have lower unsaturated plasma lipid levels compared to controls. HIGHLIGHTS: Lipid profiling showed lipid changes associated with Alzheimer's disease (AD) exclusively in women. Women with AD had fewer highly unsaturated lipids and more saturated lipids. Unsaturated phospholipids affected AD independently of cholesterol, low-density lipoprotein, or apolipoprotein B. Sex-stratified analysis is key to understanding the different manifestations of AD.
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