Evidence map›Paper›PMID 40832888›Full record

ArticleResearch in nursing & health2026

Perceived Everyday Discrimination, Dysfunctional Attitudes, and Their Influence on Depressive Symptoms and Inflammation in Youth.

Iouliana Ossipova, Patrick Pössel, Rafael Fernandez-Botran

Abstract read
In one paragraph

Article in Research in nursing & health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Iouliana OssipovaDepartment of Counseling and Human Development, University of Louisville, Louisville, Kentucky, USA.ORCID https://orcid.org/0009-0005-2853-6346
Patrick PösselDepartment of Counseling and Human Development, University of Louisville, Louisville, Kentucky, USA.ORCID https://orcid.org/0000-0002-5851-4253
Rafael Fernandez-BotranDepartment of Pathology and Laboratory Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA.ORCID http://orcid.org/0000-0001-8138-8745

Funding

This study was supported by the University of Louisville Office of Community Engagement.
6 · The paper itself

Abstract

Depressive symptoms in youth are influenced by psychosocial stressors and cognitive vulnerabilities. Perceived everyday discrimination (PED) is a common stressor linked to mental health issues, while dysfunctional attitudes (DAs), per Beck's cognitive theory of depression, may mediate these effects. Additionally, depressive symptoms have been associated with physical health outcomes, such as inflammation. We examined relationships between PED, DAs, depressive symptoms, and interleukin-6 (IL-6), a marker of inflammation, in a sample of 98 youth (13-16 years old; 36.4% female, 63.6% male) from diverse racial/ethnic backgrounds (41.4% Black/African American, 34.8% White/European American, 7.1% Multiracial, 2% Hispanic, 1% Native American, 1% Other). Measures included the Everyday Discrimination Scale, Dysfunctional Attitudes Scale, Center for Epidemiological Studies Depression Scale, and saliva samples. Our regression analyses demonstrated that PED was significantly associated with both DAs and depressive symptoms as well as that DAs were significantly associated with depressive symptoms and IL-6, while neither PED nor depressive symptoms were significantly associated with IL-6. Consistent with the regressions, our mediation analyses revealed no significant indirect effects of PED on IL-6 through DAs, depressive symptoms, or their sequential combination. Our findings support the role of PED as a stressor within Beck's cognitive theory and expand the theory's application by linking DAs to inflammatory processes. Given these connections, nurses can play a crucial role in implementing cognitive interventions to mitigate the effects of DAs and advocating for systemic change to reduce discrimination.

Indexed as

DepressionInflammationAdolescentFemaleHumansInterleukin-6MaleRacismStress, PsychologicalInterleukin-6depressive symptomsdysfunctional attitudesinflammationperceived everyday discriminationyouth

Identifiers

PMID40832888
PMCPMC13369843

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.