Evidence map›Paper›PMID 40832886›Full record

ArticleAdvanced healthcare materials2025

UV Laser-Induced Carbon Microelectrode Arrays for Neuronal Recordings.

Fulvia Del Duca, Koji Sakai, Beatrice De Chiara, Toichiro Goto, Defne Tüzün, Lukas Hiendlmeier, George Al Boustani, Hu Peng, Tetsuhiko F Teshima, Simon N Jacob and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fulvia Del DucaNeuroelectronics, Munich Institute of Biomedical Engineering, Department of Electrical Engineering, School of Computation, Information and Technology, Technical University of Munich, Hans-Piloty-Str. 1, 85748, Garching, Germany.ORCID 0000-0002-6684-173X
Koji SakaiBasic Research Laboratories, NTT, Inc., 3-1 Morinosato Wakamiya, Atsugi, Kanagawa, 243-0198, Japan.ORCID 0000-0002-5585-7074
Beatrice De ChiaraNeuroelectronics, Munich Institute of Biomedical Engineering, Department of Electrical Engineering, School of Computation, Information and Technology, Technical University of Munich, Hans-Piloty-Str. 1, 85748, Garching, Germany.ORCID 0009-0007-4901-9238
Toichiro GotoBasic Research Laboratories, NTT, Inc., 3-1 Morinosato Wakamiya, Atsugi, Kanagawa, 243-0198, Japan.ORCID 0000-0002-3099-3627
Defne TüzünNeuroelectronics, Munich Institute of Biomedical Engineering, Department of Electrical Engineering, School of Computation, Information and Technology, Technical University of Munich, Hans-Piloty-Str. 1, 85748, Garching, Germany.ORCID 0000-0001-5548-1866
Lukas HiendlmeierNeuroelectronics, Munich Institute of Biomedical Engineering, Department of Electrical Engineering, School of Computation, Information and Technology, Technical University of Munich, Hans-Piloty-Str. 1, 85748, Garching, Germany.ORCID 0000-0003-0219-6871
George Al BoustaniNeuroelectronics, Munich Institute of Biomedical Engineering, Department of Electrical Engineering, School of Computation, Information and Technology, Technical University of Munich, Hans-Piloty-Str. 1, 85748, Garching, Germany.ORCID 0000-0003-2723-8011
Hu PengNeuroelectronics, Munich Institute of Biomedical Engineering, Department of Electrical Engineering, School of Computation, Information and Technology, Technical University of Munich, Hans-Piloty-Str. 1, 85748, Garching, Germany.ORCID 0000-0001-9432-1929
Tetsuhiko F TeshimaNeuroelectronics, Munich Institute of Biomedical Engineering, Department of Electrical Engineering, School of Computation, Information and Technology, Technical University of Munich, Hans-Piloty-Str. 1, 85748, Garching, Germany.ORCID 0000-0002-9462-7167
Simon N JacobTranslational Neurotechnology Laboratory, Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, 81675, Munich, Germany.ORCID 0000-0001-9868-2158
Bernhard WolfrumNeuroelectronics, Munich Institute of Biomedical Engineering, Department of Electrical Engineering, School of Computation, Information and Technology, Technical University of Munich, Hans-Piloty-Str. 1, 85748, Garching, Germany.ORCID 0000-0003-4438-3755

Funding

Bayerisches Staatsministerium für Wissenschaft und KunstBundesministerium für Forschung, Technologie und Raumfahrt
6 · The paper itself

Abstract

Bioelectronic devices for in vitro and in vivo studies benefit from polymeric materials as substrates and insulations due to their flexible nature. Laser-induced carbon formation has emerged as a rapid and versatile technique to fabricate conductive carbon-based structures from insulating polymer films. Here, the development of electrodes fabricated via ultraviolet (UV) laser-induced carbonization of chlorinated poly-p-xylylene (parylene-C) insulation areas is reported. The parylene-derived carbon is directly fabricated over the thin metallization layer, thus opening the desired electrode areas in a one-step process. The optimal laser parameters for electrode performance are investigated, and the stability of the electrodes is tested under 10 000 voltage-controlled stimulation pulses. In vitro tests of primary neuronal cultures confirm the biocompatibility of the proposed interfaces and reveal the good conformability of the neurons over the rough carbon structures. The performance of the sensor arrays is shown in electrophysiological recordings of neuronal cultures, together with a proof-of-principle stimulation, confirming the stability of the recordings over at least 4 weeks in culture. The proposed laser-induced carbon electrodes from polymer coating are suitable as a rapid and precise fabrication protocol for carbon-based sensors, applicable to bioelectronics and neuroelectronics devices.

Indexed as

CarbonLasersNeuronsUltraviolet RaysAnimalsCells, CulturedMicroelectrodesPolymersRatsXylenesCarbonparylenePolymersXyleneslaser‐induced carbonsmulti‐electrode arraysneuronal recordingsparyleneUV lasers

Identifiers

PMID40832886
PMCPMC12645077

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.