Evidence map›Paper›PMID 40832856›Full record

ArticleTopics in stroke rehabilitation2026

The role of cognitive load on motor performance of the ipsilesional arm in stroke survivors with severe hemiparesis.

Pramisha Thapa, Lelti Asgedom, Mark Folkertsma, Scott Lunos, Diane M Chappuis, Shanie A L Jayasinghe

Abstract read
In one paragraph

Article in Topics in stroke rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pramisha ThapaDivision of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, MN, USA.
Lelti AsgedomDivision of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, MN, USA.
Mark FolkertsmaDepartment of Radiology, University of Minnesota, Minneapolis, MN, USA.
Scott LunosBiostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN, USA.
Diane M ChappuisPhysical Medicine and Rehabilitation, Courage Kenny Rehabilitation Institute, Minneapolis, MN, USA.
Shanie A L JayasingheDivision of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-4618-5170

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UM1TR004405 · NCATS · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar, Damien A Fair · 2023 to 2026
$30.8M
Technology Development ComponentP2CHD101899 · NICHD · REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB · PI DEWALD, JULIUS P · 2020 to 2024
$5.6M
The role of cognitive load on lateralized motor control processesR21HD111748 · NICHD · UNIVERSITY OF MINNESOTA · PI JAYASINGHE, SHANIE AMANDA LIYANAGAMAGE · 2023 to 2024
$426k
NCATS NIH HHS UL1 TR002494NCATS NIH HHS UM1 TR004405NICHD NIH HHS P2C HD101899NICHD NIH HHS R21 HD111748
6 · The paper itself

Abstract

backgroundIpsilesional arm motor deficits post stroke vary with the side of brain damage. Although stroke leads to both cognitive and motor impairments that can affect movement performance, the lateralized effects of cognition on motor control remain unclear.

objectivesTo examine whether changes in cognitive processes post stroke affect ipsilesional arm motor performance differently depending on the side of brain damage.

methodsWe designed a cognitively challenging upper limb reaching task on the Kinereach virtual reality motion tracking system to examine ipsilesional arm movement in 15 chronic stroke survivors with severe hemiparesis (6 left hemisphere damage, 9 right hemisphere damage; age 58 years +/- 3.09 SEM). Participants completed 170 trials in which they needed to internalize a set of pictorial instructions in order to locate and reach for the correct target.

resultsWe found that reaction time and movement error each increased with increased cognitive load (

conclusionWe found evidence of lesion side differences with respect to key measures of ipsilesional arm motor performance during a reaching task with an added cognitive challenge. Thus, these findings suggest that rehabilitation strategies should be tailored based on the side of lesions to better address hemisphere-specific motor and cognitive impairments, particularly considering that day-to-day tasks involve both motor and cognitive processes.

Indexed as

ArmCognitionFunctional LateralityParesisPsychomotor PerformanceStrokeAgedFemaleHumansMaleMiddle AgedReaction TimeSurvivorscognitive deficitscognitive loadipsilesional armlateralizationmotor deficitsStroke

Identifiers

PMID40832856
PMCPMC13127831

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.