ArticleAdvanced healthcare materials2025
ROS-Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Probiotics and Extracellular Vesicles as Redox Modulators in Wound Healing: From Microbial Therapeutics to Engineered Nanotherapeutic Strategies.Antioxidants (Basel, Switzerland) · 2026Review
- Multifunctional Self-Pumping Janus Dressing for Exudate Management and Diabetic Wound Healing.Biomolecules · 2026Article
- Engineered pagoda-like dissolvable microneedle patches for synergistic photothermal antibacterial and wound regenerative therapy.Journal of nanobiotechnology · 2026Article
- Applications of Nanomaterials in Chronic Wound Healing and Scar Prevention.International journal of nanomedicine · 2026Review
- Regulation of Tissue Regeneration by Immune Microenvironment-Fibroblast Interactions.International journal of molecular sciences · 2025Review
- ROS-Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing.Advanced healthcare materials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Chronic wounds often experience delayed healing due to a disrupted microenvironment marked by persistent inflammation and excessive fibrosiswhich leads to tissue dysfunction. Excessive mitochondrial reactive oxygen species (ROS) at the injury siteworsen this by hindering healing and promoting scarring. This study presents a multifunctional microneedle array (MNA) that combines ROS scavenging with accelerated tissue formation. The array contains Flightless I (Flii) siRNA-loaded arginine-functionalized poly (β-amino ester)-alginate (APA) particles within a hyaluronic acid methacrylate (HaMA) matrix. These siRNA-APA particles enhance ROS scavenging through nitric oxide (NO) delivery and silence Flii expression in HaCaT cells. The synergistic release of NO, arginine, and siRNA reduces pro-inflammatory gene expression (TNF-α and IL6), transforming M1 macrophages into the M2 phenotype and aiding the transition from inflammation to proliferation. Studies in a rat chronic wound model demonstrate that applying the siRNA-APA-laden MNA transdermally mitigates scar formation and promotes wound healing by reducing inflammatory responses. This siRNA-APA-laden HaMA MNA, with ROS scavenging and immunomodulatory activity, offers promising insights into effective chronic wound managementand wound dressing applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.