ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression-Associated Neuroinflammation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Bridging traditional Chinese medicine theory with advanced MOFs delivery for synergistic drug-resistant infected-chronic wound therapy.Materials today. Bio · 2026Article
- Clarifying the active ingredients & pharmacological mechanisms of traditional Chinese medicines via modern pharmaceutical analysis techniques.Journal of pharmaceutical analysis · 2026Review
- Acteoside alleviates slow transit constipation with attenuation of NLRP3 inflammasome activation and preservation of enteric neurons.Frontiers in pharmacology · 2026Article
- Acteoside exerts neuroprotective effects by preventing α-synuclein aggregation and oxidative stress in models of Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression-Associated Neuroinflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Acteoside (ACT) and ferulic acid (FA), the principal bioactive constituents of Baihe Dihuang decoction (BDD), possess established anti-inflammatory and antidepressant properties, but their combined effect on microglial phenotype modulation remains unclear. Integrated multi-source data and machine learning identified ACT and FA as BDD's core components, mediating therapeutic effects via neurotransmitter regulation and inflammatory suppression. Co-administering ACT and FA at their BDD ratio replicated the parent formulation's anti-inflammatory and antidepressant effects. Both compounds stabilized Nrf2, with ACT exhibiting greater potency. Crucially, the ACT/FA combination shifted microglia from pro-inflammatory M1 to neuroprotective M2 phenotypes via dual activation of Nrf2 and RORγt pathways. Pharmacological inhibition or genetic knockdown of Nrf2 abolished these effects, confirming its central role. This dual mechanism concurrently rectifies neuroinflammation at its microglial source and impedes peripheral immune factor invasion, effectively restoring neuroimmune homeostasis in depression. These findings provide a mechanistic foundation for optimizing herbal-derived combinatorial therapies targeting microglial polarization.
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Registered trials
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