Evidence map›Paper›PMID 40832599›Full record

ArticleFrontiers in pharmacology2025

Nobiletin protected against hypertrophic cardiomyopathy via targeting PPARα.

Kewei Zhou, Chang Chen, Hexin Cai, Zuqian Lian, Luping Wang, Qinghuo Li, Cancan Wang, Xiaoqian Wu, Panxia Wang

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kewei Zhou *School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Chang Chen *School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Hexin CaiSchool of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Zuqian LianSchool of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Luping WangSchool of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Qinghuo LiSchool of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Cancan WangSchool of Foreign Languages, Guangzhou Medical University, Guangzhou, China.
Xiaoqian WuSchool of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Panxia WangSchool of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hypertrophic cardiomyopathy is an independent risk factor for heart failure. Methods: In this study, we used network pharmacology techniques combined with bioinformatics analysis and identified the active ingredient in Results: Our results revealed that there are five main active ingredients of Conclusion: The nuclear receptor PPARα might be the potential endogenous receptor of the active ingredients of

Indexed as

Citrus reticulatahypertrophic cardiomyopathynaringeninnobiletinPPARα

Identifiers

PMID40832599
PMCPMC12358417

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.