Evidence map›Paper›PMID 40832596›Full record

ArticleInfection and drug resistance2025

Emergence, Molecular Characteristics and Resistance Mechanisms of Colistin-Resistant

Shulong Zhao, Xinyi Liang, Huihui Li, Jingfang Sun, Fei Jiang, Haiquan Kang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shulong Zhao *Department of Laboratory Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, People's Republic of China.
Xinyi Liang *School of Medical Technology, Xuzhou Medical University, Xuzhou, 221004, People's Republic of China.
Huihui Li *School of Medical Technology, Xuzhou Medical University, Xuzhou, 221004, People's Republic of China.
Jingfang SunDepartment of Laboratory Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, People's Republic of China.
Fei JiangDepartment of Laboratory Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, People's Republic of China.
Haiquan KangDepartment of Laboratory Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Carbapenem-resistant Enterobacterales (CRE) infections pose a significant global public health threat, with colistin as the last line of defense. Increasing colistin resistance presents a formidable clinical challenge. This study aimed to elucidate the molecular characteristics and resistance mechanisms of clinical colistin-resistant (ColR) CRE strains in Xuzhou, China. Methods: The broth microdilution method and PCR were performed to detect antibiotic resistance phenotype and resistance genotype. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) were used to determine genetic relatedness. Whole-genome sequencing (WGS) was carried out to characterize plasmids carrying resistance genes. Phylogenetic analysis was conducted by constructing phylogenetic tree based on single nucleotide polymorphism (SNP) and core genome multilocus sequence typing (cgMLST). Results: In 14 ColR-carbapenem-resistant Conclusion: This study underscores that mutations in the

Indexed as

carbapenem-resistantcolistinEnterobacteralesmcr-1mgrB

Identifiers

PMID40832596
PMCPMC12358502

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.