Evidence map›Paper›PMID 40832594›Full record

ArticleOpen forum infectious diseases2025

Cerebral Perfusion Pressures and Implications on Clinical Outcomes and Medical Management in Cryptococcal Meningitis.

Mahsa Abassi, Cody Hou, Ann Fieberg, Biyue Dai, Abdu K Musubire, Jetter Robertson, Lillian Tugume, Kenneth Ssebambulidde, Edwin Nuwagira, Conrad Muzoora and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mahsa AbassiDivision of Infectious Diseases, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0001-9601-3006
Cody HouDivision of Infectious Diseases, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0001-8692-6768
Ann FiebergDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Biyue DaiDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-4747-3687
Abdu K MusubireInfectious Disease Institute, College of Health Sciences, Makerere University, Kampala, Uganda.ORCID https://orcid.org/0000-0003-2410-5344
Jetter RobertsonDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-5479-1202
Lillian TugumeInfectious Disease Institute, College of Health Sciences, Makerere University, Kampala, Uganda.ORCID https://orcid.org/0000-0002-1293-1545
Kenneth SsebambuliddeInfectious Disease Institute, College of Health Sciences, Makerere University, Kampala, Uganda.ORCID https://orcid.org/0000-0002-8125-0698
Edwin NuwagiraDepartment of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Conrad MuzooraDepartment of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Darlisha A WilliamsDivision of Infectious Diseases, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
David R BoulwareDivision of Infectious Diseases, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-4715-0060
David B MeyaInfectious Disease Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
ASTRO study team

Funding

Improving Diagnostic Strategies for Post-Tuberculosis Lung Disease in Ugandan Primary Healthcare SettingsK43TW012781 · FIC · MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY · PI Edwin Nuwagira · 2024 to 2026
$327k
FIC NIH HHS K43 TW012781
6 · The paper itself

Abstract

Background: In cryptococcal meningitis, increased intracranial pressure (ICP) is associated with worse outcomes and increased mortality. We sought to understand how changes in ICP and mean arterial pressure (MAP) affect cerebral perfusion pressure (CPP) and influence clinical outcomes. Methods: We performed a secondary data analysis of a prospective cohort of Ugandan adults with HIV-associated cryptococcal meningitis. We summarize demographic variables, clinical presentation, and 2-week survival by CPP and MAP groups. Results: Among 593 participants, 41% had low CPP <70 mm Hg, 54% had normal CPP 70-100 mm Hg, and 5% had high CPP >100 mm Hg. There was no association between baseline CPP and 2-week mortality. As a time-varying covariate, we observed a 39% increased risk of 2-week mortality with CPP levels <70 or >100 mm Hg (hazard ratio [HR] 1.39; 95% confidence interval [CI] 1.02-1.88, Conclusions: In cryptococcal meningitis, there is an intricate relationship between ICP, MAP, and CPP. We provide a concept framework using data from a clinical cohort and recommendations for clinical management.

Indexed as

cerebral perfusion pressurecryptococcal meningitisintracranial pressuremean arterial pressure

Identifiers

PMID40832594
PMCPMC12359033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.