Evidence map›Paper›PMID 40832547›Full record

ArticleACS medicinal chemistry letters2025

Proline Homologation in Melanostatin Neuropeptide: Discovery of Potent Modulators of the Dopamine D

Ivo E Sampaio-Dias, Hugo F Costa-Almeida, Xavier C Correia, Sara C Silva-Reis, Vera M Costa, José Brea, María I Loza, José E Rodríguez-Borges, Xerardo García-Mera

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Dual-Acting Vitamin BJournal of medicinal chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ivo E Sampaio-DiasLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.ORCID https://orcid.org/0000-0002-9071-6197
Hugo F Costa-AlmeidaLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.ORCID https://orcid.org/0000-0002-9034-2076
Xavier C CorreiaLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.ORCID https://orcid.org/0000-0002-1440-9873
Sara C Silva-ReisLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.ORCID https://orcid.org/0000-0003-2024-0696
Vera M CostaUCIBIO - Applied Molecular Biosciences Unit, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID https://orcid.org/0000-0002-0471-2756
José BreaInnopharma Screening Platform. Biofarma Research Group. Centre of Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain.ORCID https://orcid.org/0000-0002-5523-1979
María I LozaInnopharma Screening Platform. Biofarma Research Group. Centre of Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain.ORCID https://orcid.org/0000-0003-4730-0863
José E Rodríguez-BorgesLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.ORCID https://orcid.org/0000-0002-9104-1670
Xerardo García-MeraDepartment of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain.ORCID https://orcid.org/0000-0001-5218-6351

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanostatin (MIF-1) is a naturally occurring neuropeptide acting as a positive allosteric modulator (PAM) of dopamine D

Indexed as

Dopamine D2 ReceptorsMelanostatinParkinson’s DiseasePipecolic AcidPositive Allosteric Modulators

Identifiers

PMID40832547
PMCPMC12358994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.