ArticleACS medicinal chemistry letters2025
Benzolactam-Based Gli Inhibitors: Synthesis and Structural Analysis.
Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Design of PKC-Targeting Benzolactams as Gli Inhibitors.ACS medicinal chemistry letters · 2026Article
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4 authors.
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Abstract
The Hedgehog signaling pathway plays an essential role in cancer progression, including in basal cell carcinoma and medulloblastoma. This process is driven by oncogenic Gli transcription factors, which are regulated by the signaling protein Smoothened (Smo). While Smo inhibitors have shown clinical utility, drug resistance can limit their effectiveness. Here, we present a synthetic and functional evaluation of benzolactam-derived TPPB, a potent Gli inhibitor that operates downstream of Smo via protein kinase C (PKC) activation. We developed a concise, stereoselective route to the benzolactam scaffold, enabling the synthesis of TPPB.
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