Evidence map›Paper›PMID 40832471›Full record

ArticleGastroenterology report2025

Stool-based methylated syndecan-2 testing has a high positive predictive value in an average/increased-risk population: a multicenter retrospective study.

Xinxin Huang, Song Zhang, Yanmei Liu, Xiangyu Sui, Peng Pan, Youdong Zhao, Qiwen Fang, Yongjiang Cai, Yuesheng Gong, Wang Li and 15 more

Abstract read
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In one paragraph

Article in Gastroenterology report, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Xinxin HuangDepartment of Gastroenterology/Digestive Endoscopy Center, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, P. R. China.
Song ZhangDepartment of Gastroenterology/Digestive Endoscopy Center, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, P. R. China.
Yanmei LiuDepartment of Laboratory Medicine, the Sixth School of Clinical Medicine, the Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong, P. R. China.
Xiangyu SuiDepartment of Gastroenterology/Digestive Endoscopy Center, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, P. R. China.
Peng PanDepartment of Gastroenterology/Digestive Endoscopy Center, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, P. R. China.
Youdong ZhaoDepartment of Gastroenterology/Digestive Endoscopy Center, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, P. R. China.
Qiwen FangDepartment of Gastroenterology/Digestive Endoscopy Center, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, P. R. China.
Yongjiang CaiCenter of Health Management, Peking University Shenzhen Hospital,Guangdong, P.R. China.
Yuesheng GongDepartment of Pathology, Zheng Zhou Anorectal Hospital, Zhenzhou, Henan, P. R. China.
Wang LiDepartment of Gastroenterology, The First People's Hospital of Xiushui County, Jiujiang, Jiangxi, P. R. China.
Haibo LanDepartment of Constipation, Chengdu Anorectal Hospital, Chengdu, Sichuan, P. R. China.
Yunting DengClinical Laboratory Center, Huizhou Municipal Central Hospital, Huizhou, Guangdong, P. R. China.
Yijin XuDepartment of Anorectal, Dongguan People's Hospital, Dongguan, Guangdong, P. R. China.
Zhen CaiDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.
Huiting ChenDepartment of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou, Guangdong, P. R. China.
Shaoyu HuangDepartment of Health Management, Panyu Health Management Center (Panyu Rehabilitation Hospital), Guangdong, P. R. China.
Qianchi ZhouDepartment of Health Management Center, BenQ Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
Zhanmei HuangDepartment of Health Management Center, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, P. R. China.
Bo FengDepartment of Gastroenterology, Songyuan Jilin Oilfield Hospital, Songyuan, Jilin, P. R. China.
Yinhui LiGeneral Surgery Department, Nanchang People's Hospital, Nanchang, Jiangxi, P. R. China.
Weiguo YinDepartment of Laboratory Medicine, the Sixth School of Clinical Medicine, the Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong, P. R. China.
Zhaoshen LiDepartment of Gastroenterology/Digestive Endoscopy Center, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, P. R. China.
Xiaosheng HeDepartment of General Surgery (Colorectal Surgery), Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixh Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
Shengbing ZhaoDepartment of Gastroenterology/Digestive Endoscopy Center, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, P. R. China.
Yu BaiNational Clinical Research Center for Digestive Diseases, National Quality Control Center of Digestive Endoscopy, Shanghai, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Stool DNA testing based on methylated syndecan-2 (mSDC2) is a potential novel non-invasive screening test for colorectal cancer (CRC). This study aimed to assess its positive predictive value (PPV) in real-world practice. Methods: This study retrospectively recruited consecutive patients with positive stool DNA-based SDC2 methylation tests from 18 hospitals between November 2016 and July 2021. Included patients were classified into the average-risk equivalent or increased-risk population and the previous-negative-colonoscopy or no-previous-colonoscopy groups. Multivariate logistic regression was conducted to investigate the risk factors that affect the detection of advanced colorectal neoplasia (ACN) in patients with a positive mSDC2 test. The primary outcome was the PPV for ACN. Results: The overall PPVs for ACN, CRC, and colorectal neoplasia were 28.5%, 12.8%, and 44.6%, respectively. The PPV for ACN was higher in the no-previous-colonoscopy group than in the previous-negative-colonoscopy group (30.1% vs 18.5%, Conclusions: The mSDC2 test, which has a high PPV for both ACN and CRC, is expected to be an alternative CRC screening strategy. Patients with a positive mSDC2 test might require a colonoscopy as soon as possible, even if the previous colonoscopy was negative.

Indexed as

colorectal cancerscreeningSDC2

Identifiers

PMID40832471
PMCPMC12360836

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