Evidence map›Paper›PMID 40832468›Full record

ArticleFrontiers in genetics2025

Identification of hypoxia-related diagnostic biomarkers and immune signatures in diminished ovarian reserve.

Minxue Song, Lili Ni, Zebing Ma, Xin Zhong, Yibing Liu, Jilin Kuang, Ping Li

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Minxue SongDepartment of Gynecology, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Lili NiDepartment of Orthopedics, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Zebing MaGraduate School, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Xin ZhongGraduate School, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Yibing LiuGraduate School, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Jilin KuangDepartment of Gynecology, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Ping LiDepartment of Gynecology, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diminished ovarian reserve (DOR) becomes more common with age, and hypoxia is a key cause of apoptosis in ovarian granulosa cells. This study investigated the genetic links between hypoxia and DOR. Methods: The GSE87201 dataset for DOR was sourced from Gene Expression Omnibus database, normalized for common differentially expressed genes (Co-DEGs), and identified Hypoxia-related differentially expressed genes (HRDEGs) Results: Twelve hypoxia-related genes were differentially expressed between low ovarian reserve (LOR) and high ovarian reserve (HOR), with 17 linked to DOR; eight pathways differed between LOR and HOR. Six hub genes ( Conclusion:

Indexed as

diminished ovarian reservehigh ovarian reservehypoxia-related geneimmune cell infiltrationlow ovarian reserve

Identifiers

PMID40832468
PMCPMC12358289

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